ArticleACS applied materials & interfaces2019
Sustained and Prolonged Delivery of Protein Therapeutics from Two-Dimensional Nanosilicates.
Article in ACS applied materials & interfaces, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 34 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed.
- Tunable Fabrication of 2D-Layered Magnesium Nanosilicates With Hemostatic Properties.Small science · 2026Article
- Designing the Next Generation of Biomaterials through Nanoengineering.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Nanosilicates promote angiogenesis through activation of ROS-mediated WNT/β-catenin pathway.Science advances · 2025Article
- 3D-bioprinted functional scaffold based on synergistic induction of i-PRF and laponite exerts efficient and personalized bone regeneration via miRNA-mediated TGF-β/Smads signaling.International journal of surgery (London, England) · 2025Article
- Strategies for promoting neurovascularization in bone regeneration.Military Medical Research · 2025Review
- Nanoengineered Shape-Memory Hemostat.Small science · 2025Article
- Decellularized cartilage tissue bioink formulation for osteochondral graft development.Biomedical materials (Bristol, England) · 2025Article
- LAPONITE® nano-silicates potentiate the angiogenic effects of FG-4592 and osteogenic effects of BMP-2.Biomaterials science · 2024Article
- Self-Assembled Nanocomposite Hydrogels as Carriers for Demineralized Bone Matrix Particles and Enhanced Bone Repair.Advanced healthcare materials · 2024Article
- Addition of Laponite to gelatin methacryloyl bioinks improves the rheological properties and printability to create mechanically tailorable cell culture matrices.APL bioengineering · 2024Article
- Injectable phase-separated tetra-armed poly(ethylene glycol) hydrogel scaffold allows sustained release of growth factors to enhance the repair of critical bone defects.Regenerative therapy · 2024Article
- Review
- An injectable bioactive dressing based on platelet-rich plasma and nanoclay: Sustained release of deferoxamine to accelerate chronic wound healing.Acta pharmaceutica Sinica. B · 2023Article
- Laponite-Based Nanocomposite Hydrogels for Drug Delivery Applications.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Hyaluronic acid methacrylate/laponite hydrogel loaded with BMP4 and maintaining its bioactivity for scar-free wound healing.Regenerative biomaterials · 2023Article
- Two-dimensional nanomaterials-added dynamism in 3D printing and bioprinting of biomedical platforms: Unique opportunities and challenges.Biomaterials · 2022Review
- Dissociation of nanosilicates induces downstream endochondral differentiation gene expression program.Science advances · 2022Article
- Biopolymer Nano-Network for Antimicrobial Peptide Protection and Local Delivery.Advanced healthcare materials · 2022Article
- Controlled Release of Epigenetically-Enhanced Extracellular Vesicles from a GelMA/Nanoclay Composite Hydrogel to Promote Bone Repair.International journal of molecular sciences · 2022Article
- Adsorption and Sustained Delivery of Small Molecules from Nanosilicate Hydrogel Composites.Pharmaceuticals (Basel, Switzerland) · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
Abstract
We present a nanoengineered system for sustained and prolonged delivery of protein therapeutics, which has the potential to impact current orthopedic regeneration strategies. Specifically, we introduce two-dimensional nanosilicates with a high surface area and charged characteristics for delivery of active proteins for more than 30 days. The nanosilicates show high binding efficacy without altering the protein conformation and bioactivity. The released proteins are able to maintain high activity as demonstrated by enhanced differentiation of human mesenchymal stem cells at 10-fold lower concentration compared to the exogenous control. Utilizing the nanosilicates as a delivery vehicle could minimize the negative side effects observed because of the use of supraphysiological dosages of protein therapeutics for orthopedic regeneration strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.