Evidence map›Paper›PMID 30676001›Full record

ArticleStem cells translational medicine2019

Challenges Toward the Identification of Predictive Markers for Human Mesenchymal Stromal Cells Chondrogenic Potential.

Chiara Stüdle, Paola Occhetta, Florian Geier, Arne Mehrkens, Andrea Barbero, Ivan Martin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. VCAM-1Neurochemical research · 2024
    Article
  5. Review
  6. Article
  7. Article
  8. Article
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  10. Review
  11. Article
  12. Article
  13. High-efficient generation of VCAM-1Cell proliferation · 2020
    Article
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Chiara StüdleDepartment of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.
Paola OcchettaDepartment of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.
Florian GeierDepartment of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.
Arne MehrkensDepartment of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.
Andrea BarberoDepartment of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.
Ivan MartinDepartment of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.ORCID 0000-0001-6493-0432
University of Basel · CHUniversity Hospital of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human bone marrow derived mesenchymal stromal cells (BMSCs) represent a putative cell source candidate for tissue engineering-based strategies to repair cartilage and bone. However, traditional isolation of BMSCs by adhesion to plastic leads to very heterogeneous cell populations, accounting for high variability of chondrogenic differentiation outcome, both across donors and across clonally derived strains. Identification of putative surface markers able to select BMSC subpopulations with higher chondrogenic capacity (CC) and reduced variance in chondrogenic differentiation could aid the development of BMSC-based cartilage and bone regeneration approaches. With the goal to identify predictive markers for chondrogenic BMSC populations, we assessed the gene expression profile of single cell-derived clones with high and low CC. While a clustering between high and low CC clones was observed for one donor, donor-to-donor variability hampered the possibility to achieve conclusive results when different donors were considered. Nevertheless, increased NCAM1/CD56 expression correlated in clones derived from one donor with higher CC, the same trend was observed for three additional donors (even if no significance was achieved). Enriching multiclonal BMSCs for CD56

Indexed as

AdultBiomarkersBone MarrowBone Marrow CellsCartilageCell DifferentiationCells, CulturedChondrocytesChondrogenesisFemaleHumansMaleMesenchymal Stem CellsStromal CellsTissue EngineeringBiomarkersChondrogenesisHuman bone marrow derived mesenchymal stromal cellsNCAM1/CD56RNA sequencingSelection markersTissue engineering

Identifiers

PMID30676001
PMCPMC6344903
OpenAlexW2915043530

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.