Evidence map›Paper›PMID 30675839›Full record

ArticleThe American journal of tropical medicine and hygiene2019

Research into the Causes of Venom-Induced Mortality and Morbidity Identifies New Therapeutic Opportunities.

Kesturu S Girish, Gajanan D Katkar, Robert A Harrison, Kempaiah Kemparaju

Abstract read
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kesturu S GirishDepartment of Studies and Research in Biochemistry, Tumkur University, Tumakuru, India.
Gajanan D KatkarCardiovascular Research Lab, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Robert A HarrisonCentre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Kempaiah KemparajuDepartment of Studies in Biochemistry, University of Mysore, Mysuru, India.

Funding

Medical Research Council MC_PC_15040Medical Research Council MC_PC_17167Medical Research Council MC_PC_17196Medical Research Council MR/L01839X/1National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/K500288/1
6 · The paper itself

Abstract

Snakebite primarily affects rural subsistent farming populations in underdeveloped and developing nations. The annual number of deaths (100,000) and physical disabilities (400,000) of snakebite victims is a societal tragedy that poses a significant added socioeconomic burden to the society. Antivenom therapy is the treatment of choice for snakebite but, as testified by the continuing high rates of mortality and morbidity, too many rural tropical snakebite victims fail to access effective treatment. Here, we advocate for more basic research to better understand the pathogenesis of systemic and local envenoming and describe how research outcomes can identify novel snakebite therapeutic strategies with the potential to be more accessible and affordable to victims than current treatment.

Indexed as

AnimalsAntiveninsDeoxyribonuclease IDeveloping CountriesHumansLethal Dose 50MiceMorbidityRural PopulationSnake BitesSnakesVenomsAntiveninsDeoxyribonuclease IVenoms

Identifiers

PMID30675839
PMCPMC6493937

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.