Evidence map›Paper›PMID 30675818›Full record

ArticleThe American journal of drug and alcohol abuse2019

Development of a Cascade of Care for responding to the opioid epidemic.

Arthur Robin Williams, Edward V Nunes, Adam Bisaga, Frances R Levin, Mark Olfson

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of drug and alcohol abuse, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 194 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
194citing papers in PubMed, 4 pooled it
39.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

194 citing papers in PubMed, 4 syntheses or guidelines pooled it, 328 citations in OpenAlex.

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  20. Multisite Mobile Addiction Services: Four-Year Outcomes.International journal of environmental research and public health · 2026
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134 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Arthur Robin Williamsa Department of Psychiatry , Columbia University , New York , USA.
Edward V Nunesa Department of Psychiatry , Columbia University , New York , USA.
Adam Bisagaa Department of Psychiatry , Columbia University , New York , USA.
Frances R Levina Department of Psychiatry , Columbia University , New York , USA.
Mark Olfsona Department of Psychiatry , Columbia University , New York , USA.
New York State Psychiatric InstituteColumbia University · US

Funding

Substance Abuse Treatment Development and Clinical Research MentoringK24DA029647 · NIDA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LEVIN, FRANCES RUDNICK · 2010 to 2019
$1.8M
Improving the treatment cascade of MAT initiation and retention for opioid use disorderK23DA044342 · NIDA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI WILLIAMS, ARTHUR R · 2017 to 2021
$981k
NIDA NIH HHS K23 DA044342NIDA NIH HHS K24 DA029647
6 · The paper itself

Abstract

Amid worsening opioid overdose death rates, the nation continues to face a persistent addiction treatment gap limiting access to quality care for opioid use disorder (OUD). Three FDA-approved medications (methadone, buprenorphine, and extended-release naltrexone) have high quality evidence demonstrating reductions in drug use and overdose events, but most individuals with OUD do not receive them. The development of a unified public health framework, such as a Cascade of Care, could improve system level practice and treatment outcomes. In response to feedback from many stakeholders over the past year, we have expanded upon the OUD treatment cascade, first published in 2017, with additional attention to prevention stages and both individual-level and population-based services to better inform efforts at the state and federal level. The proposed cascade framework has attracted considerable interest from federal agencies including the Centers for Disease Control and Prevention (CDC) and National Institute on Drug Abuse (NIDA) along with policy-makers nationwide. We have reviewed recent literature and evidence-based interventions related to prevention, identification, and treatment of individuals with OUD and modeled updated figures from the 2016 National Survey on Drug Use and Health. Many currently employed interventions (prescriber guidelines, prescription monitoring programs, naloxone rescue) address prevention of OUD or downstream complications but not treatment of the underlying disorder itself. An OUD Cascade of Care framework could help structure local and national efforts to combat the opioid epidemic by identifying key targets, interventions, and quality indicators across populations and settings to achieve these ends. Improved data collection and reporting methodology will be imperative.

Indexed as

Opioid EpidemicAnalgesics, OpioidDrug OverdoseHumansOpiate Substitution TreatmentOpioid-Related DisordersPublic HealthAnalgesics, OpioidHealth Services ResearchMedication Assisted TreatmentMedications for Opioid Use DisorderOpioid Use DisorderOUD Cascade of Care

Identifiers

PMID30675818
PMCPMC6404749
OpenAlexW2912522026

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.