ArticleEnvironmental health perspectives2018
Critical Windows for Associations between Manganese Exposure during Pregnancy and Size at Birth: A Longitudinal Cohort Study in Wuhan, China.
Article in Environmental health perspectives, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- The lung-brain axis: elucidating the mechanisms of pulmonary-driven neurological disorders.Journal of neuroinflammation · 2026Review
- Heavy Metal Exposure During Pregnancy and Its Association With Adverse Birth Outcomes: A Cross-Sectional Study.GeoHealth · 2025Article
- Mechanisms of bisphenol A and its analogs as endocrine disruptors via nuclear receptors and related signaling pathways.Archives of toxicology · 2025Review
- Prenatal exposure to multiple environmental chemicals and birth size.Journal of exposure science & environmental epidemiology · 2024Article
- Associations of intrauterine exposure to manganese with fetal and early-childhood growth: a prospective prenatal cohort study.Environmental science and pollution research international · 2024Article
- Exploring the link between the pediatric exposome, respiratory health, and executive function in children: a narrative review.Frontiers in public health · 2024Review
- Trimester-specific prenatal heavy metal exposures and sex-specific postpartum size and growth.Journal of exposure science & environmental epidemiology · 2023Article
- The role of endocrine disruptors in female infertility.Molecular biology reports · 2023Review
- Early-Life Critical Windows of Susceptibility to Manganese Exposure and Sex-Specific Changes in Brain Connectivity in Late Adolescence.Biological psychiatry global open science · 2023Article
- Maternal Exposure to Potentially Toxic Metals and Birth Weight: Preliminary Results from the DSAN-12M Birth Cohort in the Recôncavo Baiano, Brazil.International journal of environmental research and public health · 2023Article
- Prenatal metal mixture exposure and birth weight: A two-stage analysis in two prospective cohort studies.Eco-Environment & Health · 2022Article
- Critical windows of susceptibility in the association between manganese and neurocognition in Italian adolescents living near ferro-manganese industry.Neurotoxicology · 2021Article
- Cord Blood Manganese Concentrations in Relation to Birth Outcomes and Childhood Physical Growth: A Prospective Birth Cohort Study.Nutrients · 2021Article
- Effects of Methcathinone Exposure during Prenatal and Lactational Periods on the Development and the Learning and Memory Abilities of Rat Offspring.Neurotoxicity research · 2020Article
- Prenatal exposure to metal mixture and sex-specific birth outcomes in the New Hampshire Birth Cohort Study.Environmental epidemiology (Philadelphia, Pa.) · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrenatal overexposure to manganese (Mn), an essential micronutrient, is related to impaired fetal growth and development. Fetuses appear to be highly sensitive to Mn during short periods of gestation. However, little is known about the critical windows of susceptibility to Mn for humans.
objectivesOur objective was to estimate trimester-specific associations of exposure to Mn with size at birth.
methodsUrine samples of 3,022 women were collected repeatedly in the first, second, and third trimesters in Wuhan, China. Urinary concentrations of Mn and other toxic metals were measured using an inductively coupled plasma mass spectrometry. Trimester-specific associations of specific gravity–adjusted urinary Mn concentrations with birth weight, birth length, and ponderal index were estimated using multivariable linear regressions with generalized estimating equations. Linear mixed models were applied to evaluate the windows of susceptibility to Mn exposure by comparing the pattern of Mn exposure among newborns with restricted size at birth to those without.
resultsWhen compared with the third quintile of urinary Mn concentrations, both higher and lower quintiles of urinary Mn concentrations in the second and third trimesters were related to reduced birth weight, birth length, and ponderal index. But the observed associations for higher quintiles were stronger and more likely to be statistically significant [e.g., for women who were in the fifth quintile of Mn concentration in the third trimester, the reduction in birth weight was [Formula: see text] (95% CI: [Formula: see text], [Formula: see text]) g and in birth length was [Formula: see text] (95% CI: [Formula: see text], 0.00) cm]. Moreover, newborns with restricted size at birth, compared with those without, had higher levels of Mn exposure in the second and third trimesters.
conclusionsThis prospective prenatal cohort study revealed an association of exposure to Mn during pregnancy, especially late pregnancy, with restricted size at birth. Replications are needed. https://doi.org/10.1289/EHP3423.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.