Evidence map›Paper›PMID 30675758›Full record

ArticleJournal of cellular and molecular medicine2019

Deficiency of apoptosis-stimulating protein two of p53 ameliorates acute kidney injury induced by ischemia reperfusion in mice through upregulation of autophagy.

Jing Ji, Xiaoshuang Zhou, Ping Xu, Yafeng Li, Honglin Shi, Dexi Chen, Rongshan Li, Hongbo Shi

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Caffeine and neonatal acute kidney injury.Pediatric nephrology (Berlin, Germany) · 2024
    Review
  5. Article
  6. Article
  7. Article
  8. Florfenicol induces renal toxicity in chicks by promoting oxidative stress and apoptosis.Environmental science and pollution research international · 2021
    Article
  9. Article
  10. Review
  11. [Construction of apoptosis-stimulating of p53 protein 2 gene knockout mice and its effect on diethylnitrosamine-induced liver cancer].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2020
    Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jing JiBeijing Youan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0003-4549-828X
Xiaoshuang ZhouShanxi Provincial People's Hospital Affiliated to Shanxi Medical University, Taiyuan, China.
Ping XuBeijing Youan Hospital, Capital Medical University, Beijing, China.
Yafeng LiShanxi Provincial People's Hospital Affiliated to Shanxi Medical University, Taiyuan, China.
Honglin ShiBeijing Youan Hospital, Capital Medical University, Beijing, China.
Dexi ChenBeijing Youan Hospital, Capital Medical University, Beijing, China.
Rongshan LiShanxi Provincial People's Hospital Affiliated to Shanxi Medical University, Taiyuan, China.
Hongbo ShiBeijing Youan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0002-3666-0196
Capital Medical University · CNShanxi Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute kidney injury (AKI) has become a common disorder with a high risk of morbidity and mortality, which remains major medical problem without reliable and effective therapeutic intervention. Apoptosis-stimulating protein two of p53 (ASPP2) is a proapoptotic member that belongs to p53 binding protein family, which plays a key role in regulating apoptosis and cell growth. However, the role of ASPP2 in AKI has not been reported. To explore the role of ASPP2 in the progression of AKI, we prepared an AKI mouse model induced by ischaemia reperfusion (I/R) in wild-type (ASPP2

Indexed as

Acute Kidney InjuryAnimalsApoptosisAutophagyCell ProliferationCreatinineDisease Models, AnimalGene Expression RegulationHumansKidneyMiceMice, KnockoutReperfusion InjuryTranscriptional ActivationTranscription Factor TFIIHTumor Suppressor Protein p53CreatinineGtf2h1 protein, mouseTranscription Factor TFIIHTrp53bp2 protein, mouseTrp53 protein, mouseTumor Suppressor Protein p53Tumor Suppressor Proteinsacute kidney injuryapoptosis-stimulating protein two of p53autophagy

Identifiers

PMID30675758
PMCPMC6433670
OpenAlexW2914953632

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.