ArticleCognitive, affective & behavioral neuroscience2019
Abnormal approach-related motivation but spared reinforcement learning in MDD: Evidence from fronto-midline Theta oscillations and frontal Alpha asymmetry.
Article in Cognitive, affective & behavioral neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 27 citations in OpenAlex.
- Social functioning and frontal alpha asymmetry in schizophrenia.Journal of psychiatric research · 2025Article
- Resting-State Alpha Activity in the Frontal and Occipital Lobes and Assessment of Cognitive Impairment in Depression Patients.Psychology research and behavior management · 2024Article
- Intergenerational transmission of cognitive control capacity among children at risk for depression.Biological psychology · 2023Article
- Midfrontal mechanisms of performance monitoring continuously adapt to incoming information during outcome anticipation.Neuroimage. Reports · 2023Article
- Stress to inflammation and anhedonia: Mechanistic insights from preclinical and clinical models.Neuroscience and biobehavioral reviews · 2023Review
- A review of critical brain oscillations in depression and the efficacy of transcranial magnetic stimulation treatment.Frontiers in psychiatry · 2023Review
- The Role of Alpha Oscillations among the Main Neuropsychiatric Disorders in the Adult and Developing Human Brain: Evidence from the Last 10 Years of Research.Biomedicines · 2022Review
- Reward-Based Decision-Making Engages Distinct Modes of Cross-Frequency Coupling.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Disinhibition of right inferior frontal gyrus underlies alpha asymmetry in women with low testosterone.Biological psychology · 2021Article
- Phase-Dependent Deep Brain Stimulation: A Review.Brain sciences · 2021Review
- Women with Major Depressive Disorder, Irrespective of Comorbid Anxiety Disorders, Show Blunted Bilateral Frontal Responses during Win and Loss Anticipation.Journal of affective disorders · 2020Article
- Reward systems, cognition, and emotion: Introduction to the special issue.Cognitive, affective & behavioral neuroscience · 2019Article
- The Approach Behavior to Angry Words in Athletes-A Pilot Study.Frontiers in behavioral neuroscience · 2019Article
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Authors and funding
5 authors at 2 institutions in 1 country.
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Abstract
Major depression is characterized by abnormal reward processing and reinforcement learning (RL). This impairment might stem from deficient motivation processes, in addition to reduced reward sensitivity. In this study, we recorded 64-channel EEG in a large cohort of major depressive disorder (MDD) patients and matched healthy controls (HC) while they performed a standard RL task. Participants were asked to discover, by trial and error, several hidden stimulus-response associations having different reward probabilities, as enforced using evaluative feedback. We extracted induced fronto-midline Theta (FMT) power time-locked to the response and feedback as neurophysiological index of RL. Furthermore, we assessed approach-related motivation by measuring frontal alpha asymmetry concurrently. At the behavioral level, MDD patients and HCs showed comparable RL. At the EEG level, FMT power systematically varied as a function of reward probability, with opposing effects found at the response and feedback levels. Although this global pattern was spared in MDD, at the feedback level these patients showed however a steep FMT power decrease across trials when reward probability was low. Moreover, they showed impaired approach-related motivation during task execution, as reflected by frontal Alpha asymmetry. These results suggest a dissociation between (globally spared) RL and (impaired) approach motivation in MDD.
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