ArticleCommunications biology2019
Nanoscale mosaicity revealed in peptide microcrystals by scanning electron nanodiffraction.
Article in Communications biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Snapshots of internal protein crystal architecture at the nanoscale.Biophysical journal · 2026Article
- Multi-Crystal X-Ray Diffraction (MCXRD) Bridges the Crystallographic Characterisation Gap in Chemistry and Materials Science: Application to MOFs.Angewandte Chemie (International ed. in English) · 2026Article
- Snapshots of Internal Protein Crystal Architecture at the Nanoscale.bioRxiv : the preprint server for biology · 2026Article
- Polytypes and planar defects revealed in the purine base xanthine using multi-dimensional electron diffraction.Communications chemistry · 2025Article
- On the use of beam precession for serial electron crystallography.Journal of applied crystallography · 2025Article
- Microscopic crystallographic analysis of dislocations in molecular crystals.Nature materials · 2025Article
- Fast event-based electron counting for small-molecule structure determination by MicroED.Acta crystallographica. Section C, Structural chemistry · 2025Article
- Accounting for electron-beam-induced warping of molecular nanocrystals in MicroED structure determination.IUCrJ · 2025Article
- Article
- Reaching the potential of electron diffraction.Cell reports. Physical science · 2024Article
- 3D Nanocrystallography and the Imperfect Molecular Lattice.Annual review of physical chemistry · 2024Review
- Reassessing chain tilt in the lamellar crystals of polyethylene.Nature communications · 2023Article
- Mapping nanocrystalline disorder within an amorphous metal-organic framework.Communications chemistry · 2023Article
- Electron Diffraction of 3D Molecular Crystals.Chemical reviews · 2022Review
- Challenges in solving structures from radiation-damaged tomograms of protein nanocrystals assessed by simulation.Acta crystallographica. Section D, Structural biology · 2021Article
- Local Crystallinity in Twisted Cellulose Nanofibers.ACS nano · 2021Article
- Ab Initio Determination of Peptide Structures by MicroED.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Serial Electron Diffraction Data Processing With diffractem and CrystFEL.Frontiers in molecular biosciences · 2021Article
- Analysis of complex, beam-sensitive materials by transmission electron microscopy and associated techniques.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2020Article
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Authors and funding
11 authors.
Funding
Abstract
Changes in lattice structure across sub-regions of protein crystals are challenging to assess when relying on whole crystal measurements. Because of this difficulty, macromolecular structure determination from protein micro and nanocrystals requires assumptions of bulk crystallinity and domain block substructure. Here we map lattice structure across micron size areas of cryogenically preserved three-dimensional peptide crystals using a nano-focused electron beam. This approach produces diffraction from as few as 1500 molecules in a crystal, is sensitive to crystal thickness and three-dimensional lattice orientation. Real-space maps reconstructed from unsupervised classification of diffraction patterns across a crystal reveal regions of crystal order/disorder and three-dimensional lattice tilts on the sub-100nm scale. The nanoscale lattice reorientation observed in the micron-sized peptide crystal lattices studied here provides a direct view of their plasticity. Knowledge of these features facilitates an improved understanding of peptide assemblies that could aid in the determination of structures from nano- and microcrystals by single or serial crystal electron diffraction.
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