ArticleGE Portuguese journal of gastroenterology2018
Epidemiology of Acute Liver Failure from a Regional Liver Transplant Center in Portugal.
Article in GE Portuguese journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Liver support systems for adults with acute liver failure.The Cochrane database of systematic reviews · 2026Pooled it
- Successful Pregnancies Following Liver Transplantation for Wilson's Disease: A Case Report and Literature Review.Clinical case reports · 2026Article
- Prognostic Scores in Acute Liver Failure Due to Viral Hepatitis.Diagnostics (Basel, Switzerland) · 2023Review
- Diacerein counteracts acetaminophen-induced hepatotoxicity in mice via targeting NLRP3/caspase-1/IL-1β and IL-4/MCP-1 signaling pathways.Archives of pharmacal research · 2022Article
- Variation in the Care of Acute Liver Failure: A Survey of Intensive Care Professionals.GE Portuguese journal of gastroenterology · 2022Article
- Pregnancy after liver transplant: maternal and perinatal outcomes.BMC pregnancy and childbirth · 2021Article
- Optic Nerve Sheath Diameter in Acute Liver Failure: A Prospective Cohort Study.GE Portuguese journal of gastroenterology · 2021Article
- Liver injury induced by paracetamol and challenges associated with intentional and unintentional use.World journal of hepatology · 2020Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsAcute liver failure (ALF) is a rare disease with potentially high mortality rates. We aimed to study the recent epidemiology of ALF in one of the Portuguese liver transplant (LT) regions.
methodsWe assessed a retrospective cohort including 34 consecutive patients with ALF admitted to the intensive care unit (ICU) of Curry Cabral Hospital (Lisbon, Portugal) between October 2013 and December 2016.
resultsThe median age (IQR) was 49 (31-67) years, and 21 (62%) of the cohort were female. Non-paracetamol etiologies were found in 29 patients (85%). On ICU admission, grade 3-4 hepatic encephalopathy developed in 10 patients (29%); invasive mechanical ventilation, vasopressors, and renal replacement therapy were required for 8 (24%), 7 (21%), and 5 (15%) of the patients, respectively; the King's College criteria (KCC) were fulfilled by 16 patients (47%). Of the 15 (44%) nontransplanted patients, 11 (73%) died during their hospital stay. Of the 19 (56%) transplanted patients, 4 (21%) died during their hospital stay. KCC were not associated with hospital mortality (
conclusionsIn a Portuguese cohort of patients with ALF, non-paracetamol etiologies were predominant. Hospital mortality was much lower amongst transplanted patients.
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