ReviewVisceral medicine2018
Clinical Management of Appendicitis.
Review in Visceral medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04462588 (Are the Changes in Immature Granulocyte Count and Percentage Significant in the Decision to Continue Medical Treatment of Uncomplicated Acute Appendicitis Cases), which is not on this map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Are the Changes in Immature Granulocyte Count and Percentage Significant in the Decision to Continue Medical Treatment of Uncomplicated Acute Appendicitis Cases
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Clinical efficacy and safety of endoscopic retrograde appendicitis treatment for acute appendicitis in children: a systematic review and meta-analysis.World journal of emergency surgery : WJES · 2025Pooled it
- Comparison of Clinical Features and Outcomes of Appendectomy in Elderly vs. Non-Elderly: A Systematic Review and Meta-Analysis.Frontiers in surgery · 2022Pooled it
- Acute Appendicitis in Childhood and Adulthood.Deutsches Arzteblatt international · 2020Pooled it
- Are the immature granulocyte count and percentage important in continue medical treatment in acute appendicitis? A prospective, randomized, and controlled study.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2022Trial
- Endoscopic retrograde appendicitis therapy: Progress in clinical application.World journal of gastrointestinal endoscopy · 2026Review
- The rate of complicated appendicitis during a nonpharmaceutical intervention in two territories with different COVID-19 incidence.BMC gastroenterology · 2025Article
- Article
- Acute Medical Events in Adults with Profound Autism: A Review and Illustrative Case Series.Brain sciences · 2025Article
- Presentation management and outcome of phlegmonous and inflammed appendicitis in children in Ethiopia: retrospective review.BMC surgery · 2023Article
- Characteristics of appendicitis after immune checkpoint inhibitor therapy among cancer patients.Journal of cancer research and clinical oncology · 2023Article
- Pre-appendectomy hyponatremia is associated with increased rates of complicated appendicitis.Surgery open science · 2023Article
- Comparison of open and laparoscopic techniques in the surgical treatment of acute appendicitis.Northern clinics of Istanbul · 2023Article
- Review
- The role of CT in decision for acute appendicitis treatment.Diagnostic and interventional radiology (Ankara, Turkey) · 2022Article
- Incidence of complicated appendicitis during the COVID-19 pandemic: A systematic review and meta-analysis.International journal of surgery open · 2022Review
- Complicated Appendicitis Among Adults With and Without Disabilities: A Cross-Sectional Nationwide Study in South Korea.Frontiers in public health · 2022Article
- Acute appendicitis-advances and controversies.World journal of gastrointestinal surgery · 2021Review
- Where have all the appendicectomies gone?Annals of the Royal College of Surgeons of England · 2021Observational
- Clinical Prediction Score for Ruptured Appendicitis in ED.Emergency medicine international · 2021Article
- [Recommendations on treatment of acute appendicitis : Recommendations of an expert group based on the current literature].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEver since the first appendectomy has been performed, surgery has been the standard of care for acute appendicitis, with antibiotic therapy being reserved for special situations. Recent studies have shown the feasibility of antibiotic therapy for uncomplicated appendicitis.
methodsThis clinical therapeutic review is based both on author expertise and a selective literature survey in PubMed based on the term 'appendicitis', combined with the terms 'acute', 'complicated', 'conservative', 'non-operative', 'therapy', 'surgery', and 'strategy'. According to these search results as well as to the treatment guidelines from the American College of Surgeons, Society for Surgery of the Alimentary Tract, Society of American Gastrointestinal and Endoscopic Surgeons, European Association of Endoscopic Surgery, and World Society of Emergency Surgery, we present an interdisciplinary treatment concept.
resultsApproximately 90% of patients treated with antibiotics are able to avoid surgery during the initial admission. The other 10% that fail to respond to antibiotics require a rescue appendectomy. Recurrence rates of non-operated patients within 1 year are as high as 20-30%.
conclusionIn uncomplicated appendicitis without risk factors for failure of non-operative management, a shared decision based on the patient's preferences should be made. In cases with risk factors, appendectomy is still the treatment recommended. If the diagnosis is uncertain or clinical symptoms are rather mild, antibiotic therapy should be started. In complicated appendicitis, management depends on the clinical state, with either immediate surgery or primarily antibiotic therapy and combined with drainage of abscess, being followed by interval appendectomy in some cases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.