Evidence map›Paper›PMID 30675427›Full record

ReviewKidney international supplements2017

The establishment and validation of novel therapeutic targets to retard progression of chronic kidney disease.

Carol Pollock, Anna Zuk, Hans-Joachim Anders, Mohammad Reza Ganji, David W Johnson, Bertram Kasiske, Robyn G Langham, Roberto Pecoits-Filho, Giuseppe Remuzzi, Jerome Rossert and 5 more

Abstract readReview
In one paragraph

Review in Kidney international supplements, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Carol PollockKolling Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia.
Anna ZukAkebia Research and Development Department, Akebia Therapeutics Inc., Cambridge, Massachusetts, USA.
Hans-Joachim AndersDivision of Nephrology, Klinikum der Universität München (LMU), München, Germany.
Mohammad Reza GanjiTehran University of Medical Sciences, Shariati Hospital, Tehran, Iran.
David W JohnsonCentre for Kidney Disease Research, University of Queensland at Princess Alexandra Hospital, Brisbane, Australia.
Bertram KasiskeDepartment of Medicine, Hennepin County Medical Center, Minneapolis, Minnesota, USA.
Robyn G LanghamMonash Rural Health, Monash University, Clayton, Victoria, Australia.
Roberto Pecoits-FilhoDepartment of Internal Medicine, School of Medicine, Pontificia Universidade Catolica do Paraná, Curitiba, Brazil.
Giuseppe RemuzziIRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy.
Jerome RossertThrasos Therapeutics, Inc., Boston, Massachusetts, USA.
Yusuke SuzukiDepartment of Nephrology, Juntendo University Faculty of Medicine, Tokyo, Japan.
Tetsuhiro TanakaDivision of Nephrology and Endocrinology, The University of Tokyo School of Medicine, Tokyo, Japan.
Robert WalkerDepartment of Medicine, University of Otago, Dunedin, New Zealand.
Chih-Wei YangKidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan.
Joseph V BonventreRenal Unit, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The focus of this article is to define goals and resulting action plans that can be collectively embraced by interested stakeholders to facilitate new therapeutic approaches to mitigate chronic kidney disease progression. The specific goals include identifying druggable targets, increasing the capacity for preclinical and early clinical development, broadening the availability of new therapeutic approaches, and increasing investment in the development of new therapies to limit chronic kidney disease. Key deliverables include the establishment of new regional, national, and global consortia; development of clinical trial networks; and creation of programs to support the temporary mutual movement of scientists between academia and the biotechnology and pharmaceutical sector. Other deliverables include cataloging and maintaining up-to-date records to collate progress in renal research and development, inventorying the capacity of research and clinical networks, and describing methods to ensure novel drug development.

Indexed as

drug re-purposingpersonalized medicinetargeted treatment

Identifiers

PMID30675427
PMCPMC6341008

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.