Evidence map›Paper›PMID 30675423›Full record

ReviewKidney international supplements2017

Genetic and environmental risk factors for chronic kidney disease.

Gregorio T Obrador, Ulla T Schultheiss, Matthias Kretzler, Robyn G Langham, Masaomi Nangaku, Roberto Pecoits-Filho, Carol Pollock, Jerome Rossert, Ricardo Correa-Rotter, Peter Stenvinkel and 4 more

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Kidney international supplements, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04679168 (Change of Environmental Chemical Exposures and Prevalence of Chronic Kidney Disease After Epidemiological Spread of SARS-CoV-2), which is not on this map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04679168 unknown statusnot on this mapstarted 2020, after this paper: background citation

Change of Environmental Chemical Exposures and Prevalence of Chronic Kidney Disease After Epidemiological Spread of SARS-CoV-2 (COVID-19)

Typeobservational_patient_registrySponsorSeoul National University HospitalRan2020 to 2021Enrolled310ConditionsCovid19, Environmental Exposure, Chronic Kidney Diseases
3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Gregorio T ObradorDepartment of Epidemiology, Biostatistics and Public Health, Universidad Panamericana School of Medicine, Mexico City, Mexico.
Ulla T SchultheissInstitute of Genetic Epidemiology, Medical Center and Faculty of Medicine-University of Freiburg, Freiburg, Germany.
Matthias KretzlerDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Robyn G LanghamMonash Rural Health, Monash University, Clayton VIC, Australia.
Masaomi NangakuDepartment of Hemodialysis and Apheresis, Division of Nephrology and Endocrinology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Roberto Pecoits-FilhoDepartment of Internal Medicine, School of Medicine, Pontificia Universidade Catolica do Paraná, Curitiba, Brazil.
Carol PollockKolling Institute of Medical Research, University of Sydney, Sydney, NSW, Australia.
Jerome RossertThrasos Therapeutics, Inc., Boston, Massachusetts, USA.
Ricardo Correa-RotterDepartment of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zuibrán, Mexico City, Mexico.
Peter StenvinkelDivision of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
Robert WalkerDepartment of Medicine, University of Otago, Dunedin, New Zealand.
Chih-Wei YangKidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan.
Caroline S FoxGenetics and Pharmacogenomics, Merck Research Laboratories, Boston, Massachusetts, USA.
Anna KöttgenInstitute of Genetic Epidemiology, Medical Center and Faculty of Medicine-University of Freiburg, Freiburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In order to change the current state of chronic kidney disease knowledge and therapeutics, a fundamental improvement in the understanding of genetic and environmental causes of chronic kidney disease is essential. This article first provides an overview of the existing knowledge gaps in our understanding of the genetic and environmental causes of chronic kidney disease, as well as their interactions. The second part of the article formulates goals that should be achieved in order to close these gaps, along with suggested timelines and stakeholders that are to be involved. A better understanding of genetic and environmental factors and their interactions that influence kidney function in healthy and diseased conditions can provide novel insights into renal physiology and pathophysiology and result in the identification of novel therapeutic or preventive targets to tackle the global public health care problem of chronic kidney disease.

Indexed as

chronic kidney diseaseenvironmentgenetic kidney diseasegeneticsgenome-wide association studies

Identifiers

PMID30675423
PMCPMC6341015

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.