Evidence map›Paper›PMID 30675387›Full record

ArticleSpinal cord series and cases2019

Effects of drugs on bone metabolism in a cohort of individuals with traumatic spinal cord injury.

Christina Kokorelis, Marlis Gonzalez-Fernandez, Marjorie Morgan, Cristina Sadowsky

Open access · bronzeAbstract read
In one paragraph

Article in Spinal cord series and cases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Christina Kokorelis1Kennedy Krieger Institute, 707 N. Broadway, Baltimore, MD 21205 USA.
Marlis Gonzalez-Fernandez2Johns Hopkins University, 600 N. Wolfe St., Baltimore, MD 21287 USA.
Marjorie Morgan1Kennedy Krieger Institute, 707 N. Broadway, Baltimore, MD 21205 USA.
Cristina Sadowsky1Kennedy Krieger Institute, 707 N. Broadway, Baltimore, MD 21205 USA.ORCID 0000-0003-4028-7301
Kennedy Krieger Institute · USJohns Hopkins University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Study Design: This study is a retrospective review examining the prevalence of drugs commonly used in the management of spinal cord injury (SCI) which may influence bone health. Objective: The aim of our study was to examine the role commonly prescribed medications play in post-SCI bone health. Setting: We included all males 21 years of age and older who were evaluated over a 10-year period at an SCI-specialized center for a trauma-induced SCI. Method: We compared characteristics of individuals with normal bone mass to those with low bone mass according to their dual-energy X-ray absorptiometry (DXA) scan. Medication lists were reviewed for the presence of drugs considered to either positively or negatively affect bone metabolism. Results: Comparing individuals with normal bone mass ( Conclusions: Although 76% of our cohort was found to have low bone mass, the only major risk factors were "Time after Injury" and "Level of Injury". Anticonvulsant use was more common in individuals with low bone mass compared to those with normal bone mass. Given the retrospective methodology of this work, our findings underline associations that warrant further investigation.

Indexed as

Absorptiometry, PhotonAdultAnalgesics, OpioidAnticonvulsantsAntidepressive AgentsBone Density Conservation AgentsBone Diseases, MetabolicCalciumCase-Control StudiesDiphosphonatesFractures, SpontaneousHumansMaleMiddle AgedOsteoporosisProtective FactorsAnalgesics, OpioidAnticonvulsantsAntidepressive AgentsBone Density Conservation AgentsCalciumDiphosphonatesVitamin DAnticonvulsantsBone healthLow bone massMedication useSpinal cord injury

Identifiers

PMID30675387
PMCPMC6335409
OpenAlexW2908606109

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.