Evidence map›Paper›PMID 30675162›Full record

ArticleInternational journal of endocrinology2018

Relationship of Circulating Fetuin-A Levels with Body Size and Metabolic Phenotypes.

Hye Soo Chung, Hyun Jung Lee, Soon Young Hwang, Ju-Hee Choi, Hye Jin Yoo, Ji A Seo, Sin Gon Kim, Nan Hee Kim, Dong Seop Choi, Sei Hyun Baik and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Hepatokines as a Molecular Transducer of Exercise.Journal of clinical medicine · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Hye Soo ChungDivision of Endocrinology and Metabolism, Department of Internal Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea.
Hyun Jung LeeDivision of Endocrinology and Metabolism, Departments of Internal Medicine, Korea University, Seoul, Republic of Korea.
Soon Young HwangDepartment of Biostatistics, College of Medicine, Korea University, Seoul, Republic of Korea.
Ju-Hee ChoiDivision of Endocrinology and Metabolism, Departments of Internal Medicine, Korea University, Seoul, Republic of Korea.
Hye Jin YooDivision of Endocrinology and Metabolism, Departments of Internal Medicine, Korea University, Seoul, Republic of Korea.ORCID 0000-0003-0600-0266
Ji A SeoDivision of Endocrinology and Metabolism, Departments of Internal Medicine, Korea University, Seoul, Republic of Korea.
Sin Gon KimDivision of Endocrinology and Metabolism, Departments of Internal Medicine, Korea University, Seoul, Republic of Korea.
Nan Hee KimDivision of Endocrinology and Metabolism, Departments of Internal Medicine, Korea University, Seoul, Republic of Korea.
Dong Seop ChoiDivision of Endocrinology and Metabolism, Departments of Internal Medicine, Korea University, Seoul, Republic of Korea.
Sei Hyun BaikDivision of Endocrinology and Metabolism, Departments of Internal Medicine, Korea University, Seoul, Republic of Korea.
Kyung Mook ChoiDivision of Endocrinology and Metabolism, Departments of Internal Medicine, Korea University, Seoul, Republic of Korea.ORCID 0000-0001-6175-0225
Korea University · KRHallym University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious studies have suggested the existence of distinct body size subgroups according to metabolic health referred to as metabolically healthy obesity (MHO) and metabolically abnormal but normal weight (MANW) patients. Although nonalcoholic fatty liver disease (NAFLD) is strongly associated with obesity and metabolic syndrome, the relationship between these phenotypes and fetuin-A, a representative hepatokine, has not been explored.

methodsWe examined the association between circulating fetuin-A levels, metabolic health phenotypes, cardiometabolic risk parameters, and subclinical atherosclerosis in 290 subjects who were randomly selected from an ongoing cohort study.

resultsFetuin-A concentrations were significantly associated with detrimental anthropometric and laboratory measurements, including increased waist circumference, blood pressure, alanine aminotransferase, fasting plasma glucose, and triglyceride levels. Furthermore, fetuin-A levels were significantly increased in the metabolically abnormal (MA) group compared to the metabolically healthy (MH) group in subjects without obesity (717.1 [632.1, 769.7] vs. 599.5 [502.0, 709.3],

conclusionsThis study demonstrates that fetuin-A levels are significantly associated with metabolic health phenotypes, such as MHO and MANW, in Korean adults.

Identifiers

PMID30675162
PMCPMC6323440
OpenAlexW2906004289

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.