ReviewNature reviews. Endocrinology2019
Motilin: from gastric motility stimulation to hunger signalling.
Review in Nature reviews. Endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- The influence of herbal medicine on serum motilin and its effect on human and animal model: a systematic review.Frontiers in pharmacology · 2023Pooled it
- Effects of gastrointestinal delivery of non-caloric tastants on energy intake: a systematic review and meta-analysis.European journal of nutrition · 2021Pooled it
- Trial
- The last-step integrator thesis: Heterarchical control of the mammalian gastrointestinal tract.The Journal of physiology · 2026Review
- Article
- Evolving prokinetic therapy: New targets and therapeutic opportunities in gastrointestinal motility disorders.World journal of gastrointestinal pharmacology and therapeutics · 2026Review
- Application of traditional Chinese medicine integrated therapy based on Tuina and herbal medicine in pediatric diarrhea.World journal of gastroenterology · 2025Review
- Enteroendocrine cell differentiation: Implications for human disease.Molecular and cellular endocrinology · 2025Review
- Motilin stimulates food intake linked to gastric motility inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Pharmaceutical prokinetic and surgical interventions have opposing effects on gastroduodenal electromechanical coupling.Acta physiologica (Oxford, England) · 2025Article
- Effects of Phytosterols on Growth Performance, Serum Indexes, and Fecal Microbiota in Finishing Pigs.Animals : an open access journal from MDPI · 2025Article
- Effects ofAnimals : an open access journal from MDPI · 2024Article
- Article
- Gut microbial genomes with paired isolates from China illustrate probiotic and cardiometabolic effects.Cell genomics · 2024Article
- Common Pathophysiological Mechanisms and Treatment of Diabetic Gastroparesis.Journal of neurogastroenterology and motility · 2024Review
- In Vitro Models for Investigating Intestinal Host-Pathogen Interactions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Motilin fluctuations in healthy volunteers determined by liquid chromatography mass spectrometry.Frontiers in endocrinology · 2024Article
- Consuming artificial sweeteners may alter the structure and function of duodenal microbial communities.iScience · 2023Article
- Gastrointestinal Fermentable Polysaccharide Is Beneficial in Alleviating Loperamide-Induced Constipation in Mice.Nutrients · 2023Article
- Structural basis for motilin and erythromycin recognition by motilin receptor.Science advances · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
After the discovery of motilin in 1972, motilin and the motilin receptor were studied intensely for their role in the control of gastrointestinal motility and as targets for treating hypomotility disorders. The genetic revolution - with the use of knockout models - sparked novel insights into the role of multiple peptides but contributed to a decline in interest in motilin, as this peptide and its receptor exist only as pseudogenes in rodents. The past 5 years have seen a major surge in interest in motilin, as a series of studies have shown its relevance in the control of hunger and regulation of food intake in humans in both health and disease. Luminal stimuli, such as bitter tastants, have been identified as modulators of motilin release, with effects on hunger and food intake. The current state of knowledge and potential implications for therapy are summarized in this Review.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.