ArticleLeukemia2019
Mutant p53 enhances leukemia-initiating cell self-renewal to promote leukemia development.
Abstract readLetter
In one paragraph
Article in Leukemia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Mutant p53 promotes clonal hematopoiesis by generating a chronic inflammatory microenvironment.The Journal of clinical investigation · 2026Article
- Prognostic impact of lymphocyte to monocyte ratio in patients with myelodysplastic neoplasms/syndromes.Blood research · 2025Article
- Deciphering the molecular landscape of acute myeloid leukemia initiation and relapse: a systems biology approach.Medical oncology (Northwood, London, England) · 2025Review
- The Prognostic Value of TP53 Mutations in Adult Acute Myeloid Leukemia: A Meta-Analysis.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2023Article
- Discovery and design of dual inhibitors targeting Sphk1 and Sirt1.Journal of molecular modeling · 2023Article
- Role of p53 in regulation of hematopoiesis in health and disease.Current opinion in hematology · 2022Review
- A unique role of p53 haploinsufficiency or loss in the development of acute myeloid leukemia with FLT3-ITD mutation.Leukemia · 2022Article
- Drug Resistance Mechanisms of Acute Myeloid Leukemia Stem Cells.Frontiers in oncology · 2022Review
- Fate of Hematopoiesis During Aging. What Do We Really Know, and What are its Implications?Stem cell reviews and reports · 2020Review
- Esophageal squamous cell cancer coincides with myelodysplastic syndrome/acute myelogenous leukemia: A case report and review of the literature.Oncology letters · 2020Article
- AML chemoresistance: The role of mutant TP53 subclonal expansion and therapy strategy.Experimental hematology · 2020Review
- Article
- Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway.Nature communications · 2019Article
- p53 involvement in clonal hematopoiesis of indeterminate potential.Current opinion in hematology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Sarah C NabingerDepartment of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Sisi ChenDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Rui GaoDepartment of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Chonghua YaoDepartment of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Michihiro KobayashiDepartment of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Sasidhar VemulaDepartment of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Aidan C FaheyDepartment of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Christine WangDepartment of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Cecil DanielsDepartment of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
H Scott BoswellDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
George E SanduskyDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Lindsey D MayoDepartment of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Reuben KapurDepartment of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Yan LiuDepartment of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. liu219@iu.edu.
Funding
Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3MProject-005U54DK106846 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Reuben Kapur, Karen Elizabeth Pollok · 2015 to 2026
$9.7MBASIC SCIENCE STUDIES ON GENE THERAPY OF BLOOD DISEASEST32HL007910 · NHLBI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Roland W. Herzog, Reuben Kapur · 1999 to 2026
$7.6MMolecular mechanism underlying clonal expansion of hematopoietic stem cellsR01HL150624 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Yan Liu · 2019 to 2026
$3.8MMutant p53 rejuvenates aged stem cells through modulating epigenetic regulatorsR56AG052501 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI LIU, YAN · 2017 to 2017
$255kMolecular mechanisms underlying clonal expansion of hematopoietic stem cellsR56DK119524 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI LIU, YAN · 2018 to 2018
$150kTargeting PRL2 phosphatase in acute myeloid leukemiaF32CA203049 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI NABINGER, SARAH C. · 2016 to 2017
$121kNCATS NIH HHS UL1 TR001108NCI NIH HHS F32 CA203049NHLBI NIH HHS R01 HL150624NHLBI NIH HHS T32 HL007910NIA NIH HHS R56 AG052501NIDDK NIH HHS R56 DK119524NIDDK NIH HHS U54 DK106846U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) 1F32CA203049-01U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R56AG052501
Abstract
PubMed holds no abstract for this paper.
Indexed as
Cell Self RenewalAnimalsCell Proliferationfms-Like Tyrosine Kinase 3Leukemia, ExperimentalMiceMice, KnockoutNeoplastic Stem CellsTandem Repeat SequencesTumor Suppressor Protein p53Flt3 protein, mousefms-Like Tyrosine Kinase 3Trp53 protein, mouseTumor Suppressor Protein p53
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.