ArticleScientific reports2019
Avocado (Persea americana) fruit extract (2R,4R)-1,2,4-trihydroxyheptadec-16-yne inhibits dengue virus replication via upregulation of NF-κB-dependent induction of antiviral interferon responses.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Gastroprotective potential of fatty compounds from Persea americana seed: an experimental report.Inflammopharmacology · 2026Article
- Article
- Joint Metabolites for Avocado Oil Identity: Fatty Acid Profiles and Fatty Alcohol Esters as Unique Derivatives.Journal of agricultural and food chemistry · 2025Article
- The Pulp, Peel, Seed, and Food Products ofInternational journal of molecular sciences · 2024Review
- Cordycepin exhibits both antiviral and anti-inflammatory effects against dengue virus infection.iScience · 2024Article
- Comprehensive phytochemical characterization of Persea americana Mill. fruit via UPLC/HR-ESI-MS/MS and anti-arthritic evaluation using adjuvant-induced arthritis model.Inflammopharmacology · 2023Article
- Autochthonous Peruvian Natural Plants as Potential SARS-CoV-2 MPharmaceuticals (Basel, Switzerland) · 2023Article
- Alpha-mangostin inhibits viral replication and suppresses nuclear factor kappa B (NF-κB)-mediated inflammation in dengue virus infection.Scientific reports · 2022Article
- Therapeutic Potential of Medicinal Plants against Dengue Infection: A Mechanistic Viewpoint.ACS omega · 2022Review
- SARS-CoV-2 Remains Infectious on Refrigerated Deli Food, Meats, and Fresh Produce for up to 21 Days.Foods (Basel, Switzerland) · 2022Article
- Tropical Fruits and Their Co-Products as Bioactive Compounds and Their Health Effects: A Review.Foods (Basel, Switzerland) · 2021Review
- Structure-activity relationship of avocadyne.Food & function · 2021Article
- Therapeutic potential of phytoconstituents of edible fruits in combating emerging viral infections.Journal of food biochemistry · 2021Review
- Echinacea purpurea (L.) Moench treatment of monocytes promotes tonic interferon signaling, increased innate immunity gene expression and DNA repeat hypermethylated silencing of endogenous retroviral sequences.BMC complementary medicine and therapies · 2021Article
- Production, Transmission, Pathogenesis, and Control of Dengue Virus: A Literature-Based Undivided Perspective.BioMed research international · 2021Review
- Avocado-derived polyols for use as novel co-surfactants in low energy self-emulsifying microemulsions.Scientific reports · 2020Article
- The Odyssey of Bioactive Compounds in Avocado (Antioxidants (Basel, Switzerland) · 2019Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dengue virus (DENV) caused millions of infections around the world annually. Co-infection with different serotypes of DENV is associated with dengue hemorrhagic shock syndrome, leading to an estimate of 50% death rate. No approved therapies are currently available for the treatment of DENV infection. Hence, novel anti-DENV agents are urgently needed for medical therapy. Here we demonstrated that a natural product (2 R,4 R)-1,2,4-trihydroxyheptadec-16-yne (THHY), extracted from avocado (Persea americana) fruit, can inhibit DENV-2 replication in a concentration-dependent manner and efficiently suppresses replication of all DENV serotypes (1-4). We further reveal that the NF-κB-mediated interferon antiviral response contributes to the inhibitory effect of THHY on DENV replication. Using a DENV-infected ICR suckling mouse model, we found that THHY treatment caused an increased survival rate among mice infected with DENV. Collectively, these findings support THHY as a potential agent to control DENV infection.
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