Trial reportScientific reports2019
Sad faces increase the heartbeat-associated interoceptive information flow within the salience network: a MEG study.
Trial report in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Heartbeat-Evoked Responses in M/EEG: A Systematic Review of Methods With Suggestions for Analysis and Reporting.Psychophysiology · 2026Pooled it
- Interoceptive predictors of daily functioning in aging and their interaction with exteroceptive bodily representations.Frontiers in psychology · 2026Article
- Characterizing the Heartbeat-Evoked Potential: A Two-Component Model of Cardiac Signal Processing?Psychophysiology · 2025Article
- Predictive role of exteroceptive and interoceptive bodily dimensions to schizotypal personality traits.Scientific reports · 2025Article
- Contingency learning of social cues: neural engagement and emotional modulation by facial expressions.Frontiers in human neuroscience · 2025Article
- Interoceptive rhythms in the brain.Nature neuroscience · 2023Review
- Whose emotion is it? Perspective matters to understand brain-body interactions in emotions.NeuroImage · 2023Article
- Cardiac-Brain Dynamics Depend on Context Familiarity and Their Interaction Predicts Experience of Emotional Arousal.Brain sciences · 2022Article
- Cardiac sympathetic-vagal activity initiates a functional brain-body response to emotional arousal.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Interoception Dysfunction Contributes to the Negative Emotional Bias in Major Depressive Disorder.Frontiers in psychiatry · 2022Article
- Interoception Primes Emotional Processing: Multimodal Evidence from Neurodegeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Expanding Simulation Models of Emotional Understanding: The Case for Different Modalities, Body-State Simulation Prominence, and Developmental Trajectories.Frontiers in psychology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The somatic marker hypothesis proposes that the cortical representation of visceral signals is a crucial component of emotional processing. No previous study has investigated the information flow among brain regions that process visceral information during emotional perception. In this magnetoencephalography study of 32 healthy subjects of either sex, heartbeat-evoked responses (HERs), which reflect the cortical processing of heartbeats, were modulated by the perception of a sad face. The modulation effect was localized to the prefrontal cortices, the globus pallidus, and an interoceptive network including the right anterior insula (RAI) and dorsal anterior cingulate cortex (RdACC). Importantly, our Granger causality analysis provides the first evidence for the increased flow of heartbeat information from the RAI to the RdACC during sad face perception. Moreover, using a surrogate R-peak analysis, we have shown that this HER modulation effect was time-locked to heartbeats. These findings advance the understanding of brain-body interactions during emotional processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.