Evidence map›Paper›PMID 30674985›Full record

ArticleScientific reports2019

Pro-resolving lipid mediator ameliorates obesity induced osteoarthritis by regulating synovial macrophage polarisation.

Antonia Rujia Sun, Xiaoxin Wu, Bohao Liu, Yang Chen, Charles W Armitage, Avinash Kollipara, Ross Crawford, Kenneth W Beagley, Xinzhan Mao, Yin Xiao and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 82 citations in OpenAlex.

  1. Review
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  9. The research progress and potential applications ofThe British journal of nutrition · 2025
    Review
  10. Article
  11. Article
  12. Liposome-Based Interventions in Knee Osteoarthritis.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Review
  13. Review
  14. Effects of iron overload in human joint tissue explant cultures and animal models.Journal of molecular medicine (Berlin, Germany) · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Antonia Rujia SunInstitute of Health and Biomedical Innovation, Faculty of Science and Engineering, Queensland University of Technology, Brisbane, 4059, Australia.
Xiaoxin WuDepartment of Orthopaedic Surgery, Second Xiangya Hospital, Central South University, Changsha, China.
Bohao LiuDepartment of Orthopaedic Surgery, Second Xiangya Hospital, Central South University, Changsha, China.
Yang ChenDepartment of Orthopaedic Surgery, Second Xiangya Hospital, Central South University, Changsha, China.
Charles W ArmitageInstitute of Health and Biomedical Innovation, Faculty of Health, School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia.
Avinash KolliparaInstitute of Health and Biomedical Innovation, Faculty of Health, School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia.
Ross CrawfordInstitute of Health and Biomedical Innovation, Faculty of Science and Engineering, Queensland University of Technology, Brisbane, 4059, Australia.
Kenneth W BeagleyInstitute of Health and Biomedical Innovation, Faculty of Health, School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia.
Xinzhan MaoDepartment of Orthopaedic Surgery, Second Xiangya Hospital, Central South University, Changsha, China. maoxinzhan72@126.com.
Yin XiaoInstitute of Health and Biomedical Innovation, Faculty of Science and Engineering, Queensland University of Technology, Brisbane, 4059, Australia.
Indira PrasadamInstitute of Health and Biomedical Innovation, Faculty of Science and Engineering, Queensland University of Technology, Brisbane, 4059, Australia. i.prasadam@qut.edu.au.
Queensland University of Technology · AUCentral South University · CNSecond Xiangya Hospital of Central South University · CNUniversity of North Carolina at Chapel Hill · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-resolved persistent macrophage-mediated synovial inflammation is considered as one of the main drivers of both the establishment and progression of obesity-associated osteoarthritis (OA). Herein, we used clodronate-loaded liposomes (CL) to locally deplete macrophages in the synovial joints to examine the role of macrophages in the progression of obesity-induced OA. Furthermore, resolvin D1 (RvD1), a unique family of pro-resolving lipid mediator derived from the omega-3 polyunsaturated fatty acid, have shown marked potency in changing the pro-inflammatory behaviour of the macrophages. We sought to determine whether RvD1 administration ameliorates obesity-induced OA by resolving macrophage-mediated synovitis. Therapeutic properties of RvD1 and macrophage depletion (CL) were tested for its ability to slow post-traumatic OA (PTOA) in obese mice models. PTOA was induced in C57Bl/6 mice fed with high-fat diet (HFD) by surgically destabilising the meniscus. Firstly, CL treatment showed beneficial effects in reducing synovitis and cartilage destruction in obese mice with PTOA. In vitro treatment with RvD1 decreased the levels of pro-inflammatory markers in CD14+ human macrophages. Furthermore, intra-articular treatment with RvD1 diminishes the progression of OA in the knee joint from mice as follows: (a) decreases macrophages infiltration in synovium, (b) reduces the number of pro-inflammatory macrophages in synovium and (c) improves the severity of synovitis and cartilage degradation. Thus, our results provide new evidence for the potential targeting of macrophages in the treatment of obesity-induced OA.

Indexed as

AnimalsDietary FatsDisease Models, AnimalDocosahexaenoic AcidsHumansInflammation MediatorsMacrophagesMaleMiceObesityOsteoarthritisSynovial MembraneDietary FatsDocosahexaenoic AcidsInflammation Mediatorsresolvin D1

Identifiers

PMID30674985
PMCPMC6344566
OpenAlexW2914844086

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.