Evidence map›Paper›PMID 30674943›Full record

Trial reportScientific reports2019

Lung resistance-related protein (LRP) predicts favorable therapeutic outcome in Acute Myeloid Leukemia.

Bibi Kulsoom, Tahir Sultan Shamsi, Nasir Ali Afsar

Open access · goldAbstract readClinical Trial
In one paragraph

Trial report in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Bibi KulsoomNational Institute of Blood Diseases and Bone Marrow Transplantation, Karachi, Pakistan. drknpk@yahoo.com.
Tahir Sultan ShamsiNational Institute of Blood Diseases and Bone Marrow Transplantation, Karachi, Pakistan.ORCID 0000-0001-7667-5838
Nasir Ali AfsarJinnah Medical and Dental College, Karachi, Pakistan.
Jinnah Medical & Dental College · PKNational Institute Of Blood Disease and Bone Marrow Transplantation · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is conflicting evidence that MDR1, MRP2 and LRP expression is responsible for chemotherapy resistance. We conducted this study to explore their role in AML therapy outcomes. Bone marrow and peripheral blood samples of 90 AML patients, receiving chemotherapy, were analyzed by real time PCR. Gene expression was calculated by the 2

Indexed as

Drug Resistance, NeoplasmLeukemia, Promyelocytic, AcuteAdolescentAdultAntineoplastic Combined Chemotherapy ProtocolsATP-Binding Cassette Sub-Family B Member 4ATP Binding Cassette Transporter, Subfamily BBone MarrowCytarabineDaunorubicinFemaleHumansMajor Vault ProteinMaleMiddle AgedNeoplasm ProteinsABCB1 protein, humanATP-Binding Cassette Sub-Family B Member 4ATP Binding Cassette Transporter, Subfamily BCytarabineDaunorubicinMajor Vault ProteinNeoplasm ProteinsVault Ribonucleoprotein Particles

Identifiers

PMID30674943
PMCPMC6344578
OpenAlexW2914104021

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.