ArticleNature communications2019
Structure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- Involvement of the African swine fever virus protein pH108R in virion morphogenesis.Emerging microbes & infections · 2026Article
- Engineering a Virus-Derived X Family DNA Polymerase FvPolX for de novo DNA Synthesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Thonningianin A disrupts pA104R-DNA binding and inhibits African swine fever virus replication.Emerging microbes & infections · 2025Article
- Article
- Nucleic acid joining enzymes: biological functions and synthetic applications beyond DNA.The Biochemical journal · 2025Review
- Cryo-EM structure of DNA polymerase of African swine fever virus.Nucleic acids research · 2024Article
- Massive expansion of the pig gut virome based on global metagenomic mining.NPJ biofilms and microbiomes · 2024Article
- Structures of African swine fever virus topoisomerase complex and their implications.Nature communications · 2024Article
- Four Parallel Pathways in T4 Ligase-Catalyzed Repair of Nicked DNA with Diverse Bending Angles.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Review
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- Viral replication organelles: the highly complex and programmed replication machinery.Frontiers in microbiology · 2024Review
- Article
- Structures and implications of the C962R protein of African swine fever virus.Nucleic acids research · 2023Article
- Structural and functional studies of PCNA from African swine fever virus.Journal of virology · 2023Article
- The Structural Basis of African Swine Fever Virus pS273R Protease Binding to E64 through Molecular Dynamics Simulations.Molecules (Basel, Switzerland) · 2023Article
- Tracing the Origin of Genotype II African Swine Fever Virus in China by Genomic Epidemiology Analysis.Transboundary and emerging diseases · 2023Article
- Integrated agronomic, physiological, microstructure, and whole-transcriptome analyses reveal the role of biomass accumulation and quality formation during Se biofortification in alfalfa.Frontiers in plant science · 2023Article
- Complete Structural Predictions of the Proteome of African Swine Fever Virus Strain Georgia 2007.Microbiology resource announcements · 2022Article
- Structures of LIG1 that engage with mutagenic mismatches inserted by polβ in base excision repair.Nature communications · 2022Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
African swine fever virus (ASFV) is contagious and can cause highly lethal disease in pigs. ASFV DNA ligase (AsfvLIG) is one of the most error-prone ligases identified to date; it catalyzes DNA joining reaction during DNA repair process of ASFV and plays important roles in mutagenesis of the viral genome. Here, we report four AsfvLIG:DNA complex structures and demonstrate that AsfvLIG has a unique N-terminal domain (NTD) that plays critical roles in substrate binding and catalytic complex assembly. In combination with mutagenesis, in vitro binding and catalytic assays, our study reveals that four unique active site residues (Asn153 and Leu211 of the AD domain; Leu402 and Gln403 of the OB domain) are crucial for the catalytic efficiency of AsfvLIG. These unique structural features can serve as potential targets for small molecule design, which could impair genome repair in ASFV and help combat this virus in the future.
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