Evidence map›Paper›PMID 30674860›Full record

ArticleGels (Basel, Switzerland)2018

Low-Cost Microfluidic Sensors with Smart Hydrogel Patterned Arrays Using Electronic Resistive Channel Sensing for Readout.

Hsuan-Yu Leu, Navid Farhoudi, Christopher F Reiche, Julia Körner, Swomitra Mohanty, Florian Solzbacher, Jules Magda

Abstract read
In one paragraph

Article in Gels (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Catheter-mounted smart hydrogel ultrasound resonators for intravenous analyte monitoring.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2021
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hsuan-Yu LeuDepartment of Chemical Engineering, University of Utah, Salt Lake City, UT 84112, USA. h.leu@utah.edu.ORCID 0000-0002-2617-1890
Navid FarhoudiDepartment of Electrical & Computer Engineering, University of Utah, Salt Lake City, UT 84112, USA. navid.farhoudi@utah.edu.ORCID 0000-0002-6415-950X
Christopher F ReicheDepartment of Electrical & Computer Engineering, University of Utah, Salt Lake City, UT 84112, USA. christopher.reiche@utah.edu.
Julia KörnerDepartment of Electrical & Computer Engineering, University of Utah, Salt Lake City, UT 84112, USA. julia.koerner@utah.edu.
Swomitra MohantyDepartment of Chemical Engineering, University of Utah, Salt Lake City, UT 84112, USA. swomitra@chemeng.utah.edu.
Florian SolzbacherDepartment of Electrical & Computer Engineering, University of Utah, Salt Lake City, UT 84112, USA. florian.solzbacher@utah.edu.
Jules MagdaDepartment of Chemical Engineering, University of Utah, Salt Lake City, UT 84112, USA. jj.magda@utah.edu.

Funding

Joe W. and Dorothy Dorsett Brown Foundation 9999University of utah research foundation 9999
6 · The paper itself

Abstract

There is a strong commercial need for inexpensive point-of-use sensors for monitoring disease biomarkers or environmental contaminants in drinking water. Point-of-use sensors that employ smart polymer hydrogels as recognition elements can be tailored to detect almost any target analyte, but often suffer from long response times. Hence, we describe here a fabrication process that can be used to manufacture low-cost point-of-use hydrogel-based microfluidics sensors with short response times. In this process, mask-templated UV photopolymerization is used to produce arrays of smart hydrogel pillars inside sub-millimeter channels located upon microfluidics devices. When these pillars contact aqueous solutions containing a target analyte, they swell or shrink, thereby changing the resistance of the microfluidic channel to ionic current flow when a small bias voltage is applied to the system. Hence resistance measurements can be used to transduce hydrogel swelling changes into electrical signals. The only instrumentation required is a simple portable potentiostat that can be operated using a smartphone or a laptop, thus making the system suitable for point of use. Rapid hydrogel response rate is achieved by fabricating arrays of smart hydrogels that have large surface area-to-volume ratios.

Indexed as

fast response timemicrofluidic sensorssmart hydrogelsUV photopolymerization

Identifiers

PMID30674860
PMCPMC6318584

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.