Evidence map›Paper›PMID 30674849›Full record

ArticleGels (Basel, Switzerland)2018

A Comparative Study of a 3D Bioprinted Gelatin-Based Lattice and Rectangular-Sheet Structures.

Shweta Anil Kumar, Nishat Tasnim, Erick Dominguez, Shane Allen, Laura J Suggs, Yoshihiro Ito, Binata Joddar

Abstract read
In one paragraph

Article in Gels (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. 3D Bioprinting of cardiac tissue and cardiac stem cell therapy.Translational research : the journal of laboratory and clinical medicine · 2019
    Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shweta Anil KumarInspired Materials & Stem-Cell Based Tissue Engineering Laboratory (IMSTEL), Department of Metallurgical, Materials and Biomedical Engineering, University of Texas at El Paso, 500 W University Avenue, El Paso, TX 79968, USA. sanilkumar@miners.utep.edu.
Nishat TasnimInspired Materials & Stem-Cell Based Tissue Engineering Laboratory (IMSTEL), Department of Metallurgical, Materials and Biomedical Engineering, University of Texas at El Paso, 500 W University Avenue, El Paso, TX 79968, USA. ntasnim@miners.utep.edu.
Erick DominguezInspired Materials & Stem-Cell Based Tissue Engineering Laboratory (IMSTEL), Department of Metallurgical, Materials and Biomedical Engineering, University of Texas at El Paso, 500 W University Avenue, El Paso, TX 79968, USA. edominguez26@miners.utep.edu.
Shane AllenDepartment of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA. shaneallen216@gmail.com.
Laura J SuggsDepartment of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA. suggs@utexas.edu.
Yoshihiro ItoNano Medical Engineering Laboratory, RIKEN Custer for Pioneering Research, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan. y-ito@riken.jp.ORCID 0000-0002-1154-253X
Binata JoddarInspired Materials & Stem-Cell Based Tissue Engineering Laboratory (IMSTEL), Department of Metallurgical, Materials and Biomedical Engineering, University of Texas at El Paso, 500 W University Avenue, El Paso, TX 79968, USA. bjoddar@utep.edu.

Funding

Bioprinting of human iPSCs to facilitate their differentiation, recruitment and strategic assembly to form engineered cardiac patchesSC2HL134642 · NHLBI · UNIVERSITY OF TEXAS EL PASO · PI JODDAR, BINATA · 2016 to 2018
$438k
BUILDing SCHOLARS (Research Enrichment Core)RL5MD009592 · NIMHD · UNIVERSITY OF TEXAS EL PASO · PI AGUILERA, RENATO J, ALEY, STEPHEN B · 2014 to 2014
$268k
NHLBI NIH HHS SC2 HL134642NIH HHS NIH 1SC2HL134642-01NIH HHS NIH BUILD Pilot 8UL1GM118970-02
6 · The paper itself

Abstract

3D bioprinting holds great promise in the field of regenerative medicine as it can create complex structures in a layer-by-layer manner using cell-laden bioinks, making it possible to imitate native tissues. Current bioinks lack both high printability and biocompatibility required in this respect. Hence, the development of bioinks that exhibit both properties is needed. In our previous study, a furfuryl-gelatin-based bioink, crosslinkable by visible light, was used for creating mouse mesenchymal stem cell-laden structures with a high fidelity. In this study, lattice mesh geometries were printed in a comparative study to test against the properties of a traditional rectangular-sheet. After 3D printing and crosslinking, both structures were analysed for swelling and rheological properties, and their porosity was estimated using scanning electron microscopy. The results showed that the lattice structure was relatively more porous with enhanced rheological properties and exhibited a lower degradation rate compared to the rectangular-sheet. Further, the lattice allowed cells to proliferate to a greater extent compared to the rectangular-sheet, which initially retained a lower number of cells. All of these results collectively affirmed that the lattice poses as a superior scaffold design for tissue engineering applications.

Indexed as

3D bioprintingcardiac patchesfurfuryl-gelatinhydrogelslattice

Identifiers

PMID30674849
PMCPMC6209247

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.