ArticleProceedings of the National Academy of Sciences of the United States of America2019
Interrelationships between structure and function during the hemostatic response to injury.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 81 citations in OpenAlex.
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- Thrombin activity confinement and dense granule release drive the dynamics of arterial thrombus.PLoS computational biology · 2026Article
- Neutrophil cathepsin G potentiates biased signaling through protease-activated receptor 4.Blood advances · 2026Article
- The clot thickens: transverse cables under high shear flow.Blood advances · 2025Article
- Arterial human blood flow can be stopped by cables of VWF and platelets without coagulation.Blood advances · 2025Article
- Tinkering with Blood: Optimizing the Coagulation System for Therapeutic Purposes.Bioengineering (Basel, Switzerland) · 2025Review
- The Syk inhibitor BI 1002494 impairs thrombus infill in a murine femoral artery occlusion without affecting hemostasis.Blood vessels, thrombosis & hemostasis · 2025Article
- From imaging to computational domains for physics-driven molecular biology simulations: Hindered diffusion in platelet masses.PLoS computational biology · 2025Article
- Mechanical Biomimetic Nanocomposites for Multidimensional Treatment of Arterial Thrombosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Innovative Application of Medicinal Insects: Employing UHPLC-MS, Bioinformatics, In Silico Studies andPharmaceuticals (Basel, Switzerland) · 2025Article
- Impact of antiplatelet therapy on hemostatic plug formation in the setting of thrombocytopenia.Research and practice in thrombosis and haemostasis · 2025Article
- Phosphatidylserine-blocking nanoparticles inhibit thrombosis without increased bleeding in mice.Journal of thrombosis and haemostasis : JTH · 2025Article
- Article
- Mosquito salivary apyrase regulates blood meal hemostasis and facilitates malaria parasite transmission.Nature communications · 2024Article
- Advances and applications of biomimetic biomaterials for endogenous skin regeneration.Bioactive materials · 2024Review
- Puncture Wound Hemostasis and Preparation of Samples for Montaged Wide-Area Electron Microscopy Analysis.Journal of visualized experiments : JoVE · 2024Article
- Dual antithrombotic therapy dose-dependently alters hemostatic plug structure and function.Journal of thrombosis and haemostasis : JTH · 2024Article
- Plasma growth factors maintain constitutive translation in platelets to regulate reactivity and thrombotic potential.Blood advances · 2024Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Extensive studies have detailed the molecular regulation of individual components of the hemostatic system, including platelets, coagulation factors, and regulatory proteins. Questions remain, however, about how these elements are integrated at the systems level within a rapidly changing physical environment. To answer some of these questions, we developed a puncture injury model in mouse jugular veins that combines high-resolution, multimodal imaging with functional readouts in vivo. The results reveal striking spatial regulation of platelet activation and fibrin formation that could not be inferred from studies performed ex vivo. As in the microcirculation, where previous studies have been performed, gradients of platelet activation are readily apparent, as is an asymmetrical distribution of fibrin deposition and thrombin activity. Both are oriented from the outer to the inner surface of the damaged vessel wall, with a greater extent of platelet activation and fibrin accumulation on the outside than the inside. Further, we show that the importance of P2Y
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