Evidence map›Paper›PMID 30674669›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Robust predictions of specialized metabolism genes through machine learning.

Bethany M Moore, Peipei Wang, Pengxiang Fan, Bryan Leong, Craig A Schenck, John P Lloyd, Melissa D Lehti-Shiu, Robert L Last, Eran Pichersky, Shin-Han Shiu

Erratum issuedAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed.

  1. Review
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  11. Using supervised machine-learning approaches to understand abiotic stress tolerance and design resilient crops.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  12. Review
  13. Review
  14. Understanding metabolic diversification in plants: branchpoints in the evolution of specialized metabolism.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Review
  15. Article
  16. Enhancing Withanolide Production in thePlants (Basel, Switzerland) · 2024
    Review
  17. Article
  18. Article
  19. Machine learning enables identification of an alternative yeast galactose utilization pathway.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Bethany M MooreDepartment of Plant Biology, Michigan State University, East Lansing, MI 48824.ORCID 0000-0002-2104-7292
Peipei WangDepartment of Plant Biology, Michigan State University, East Lansing, MI 48824.
Pengxiang FanDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824.ORCID 0000-0002-4560-3783
Bryan LeongDepartment of Plant Biology, Michigan State University, East Lansing, MI 48824.ORCID 0000-0003-4042-1160
Craig A SchenckDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824.
John P LloydDepartment of Human Genetics, University of Michigan, Ann Arbor, MI 48109.
Melissa D Lehti-ShiuDepartment of Plant Biology, Michigan State University, East Lansing, MI 48824.
Robert L LastDepartment of Plant Biology, Michigan State University, East Lansing, MI 48824.ORCID 0000-0001-6974-9587
Eran PicherskyDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109.
Shin-Han ShiuDepartment of Plant Biology, Michigan State University, East Lansing, MI 48824; shius@msu.edu.ORCID 0000-0001-6470-235X

Funding

Plant Biotechnology for Health and SustainabilityT32GM110523 · NIGMS · MICHIGAN STATE UNIVERSITY · PI LAST, ROBERT LOUIS · 2014 to 2023
$2.2M
NIGMS NIH HHS T32 GM110523
6 · The paper itself

Abstract

Plant specialized metabolism (SM) enzymes produce lineage-specific metabolites with important ecological, evolutionary, and biotechnological implications. Using

Indexed as

data integrationmachine learningpredictive biologyspecialized metabolism

Identifiers

PMID30674669
PMCPMC6369796

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.