ArticleProceedings of the National Academy of Sciences of the United States of America2019
Modulation of tissue growth heterogeneity by responses to mechanical stress.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 24 citations in OpenAlex.
- ROS inhibits microtubule dynamics and cell growth heterogeneity during Arabidopsis sepal morphogenesis.iScience · 2026Article
- Self-organization underlies developmental robustness in plants.Cells & development · 2025Review
- Identifying Heterogeneous Micromechanical Properties of Biological Tissues via Physics-Informed Neural Networks.Small methods · 2025Article
- Article
- Growth couples temporal and spatial fluctuations of tissue properties during morphogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Growth couples temporal and spatial fluctuations of tissue properties during morphogenesis.bioRxiv : the preprint server for biology · 2024Article
- The dynamics and biophysics of shape formation: Common themes in plant and animal morphogenesis.Developmental cell · 2023Review
- Stiffness transitions in new walls post-cell division differ betweenProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Cycling in a crowd: Coordination of plant cell division, growth, and cell fate.The Plant cell · 2022Review
- Growth dynamics of theProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Statistics of noisy growth with mechanical feedback in elastic tissues.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Mechanical Conflicts in Twisting Growth Revealed by Cell-Cell Adhesion Defects.Frontiers in plant science · 2019Article
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2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Morphogenesis often yields organs with robust size and shapes, whereas cell growth and deformation feature significant spatiotemporal variability. Here, we investigate whether tissue responses to mechanical signals contribute to resolve this apparent paradox. We built a model of growing tissue made of fiber-like material, which may account for the cytoskeleton, polar cell-cell adhesion, or the extracellular matrix in animals and for the cell wall in plants. We considered the synthesis and remodeling of this material, as well as the modulation of synthesis by isotropic and anisotropic response to mechanical stress. Formally, our model describes an expanding, mechanoresponsive, nematic, and active fluid. We show that mechanical responses buffer localized perturbations, with two possible regimes-hyporesponsive and hyperresponsive-and the transition between the two corresponds to a minimum value of the relaxation time. Whereas robustness of shapes suggests that growth fluctuations are confined to small scales, our model yields growth fluctuations that have long-range correlations. This indicates that growth fluctuations are a significant source of heterogeneity in development. Nevertheless, we find that mechanical responses may dampen such fluctuations, with a specific magnitude of anisotropic response that minimizes heterogeneity of tissue contours. We finally discuss how our predictions might apply to the development of plants and animals. Altogether, our results call for the systematic quantification of fluctuations in growing tissues.
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