Evidence map›Paper›PMID 30674648›Full record

ArticlemSphere2019

Repurposing Pilocarpine Hydrochloride for Treatment of Candida albicans Infections.

Christopher Nile, Monica Falleni, Daniela Cirasola, Abeer Alghamdi, Oliver F Anderson, Christopher Delaney, Gordon Ramage, Emerenziana Ottaviano, Delfina Tosi, Gaetano Bulfamante and 2 more

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Pilocarpine inhibitsMicrobiology spectrum · 2025
    Article
  2. Journal of fungi (Basel, Switzerland) · 2025
    Review
  3. Article
  4. Article
  5. Review
  6. Therapeutic Effect of an Antibody-Derived Peptide in aInternational journal of molecular sciences · 2021
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Antifungal Drug Repurposing.Antibiotics (Basel, Switzerland) · 2020
    Article
  12. Microorganisms · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Christopher NileOral Sciences Research Group, University of Glasgow Dental School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom christopher.nile@glasgow.ac.uk.
Monica FalleniDivision of Human Pathology, Department of Health Sciences, Università degli Studi di Milano, Milan, Italy.
Daniela CirasolaLaboratory of Microbiology, Department of Health Sciences, Università degli Studi di Milano, Milan, Italy.
Abeer AlghamdiOral Sciences Research Group, University of Glasgow Dental School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Oliver F AndersonOral Sciences Research Group, University of Glasgow Dental School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Christopher DelaneyOral Sciences Research Group, University of Glasgow Dental School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Gordon RamageOral Sciences Research Group, University of Glasgow Dental School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Emerenziana OttavianoLaboratory of Microbiology, Department of Health Sciences, Università degli Studi di Milano, Milan, Italy.
Delfina TosiDivision of Human Pathology, Department of Health Sciences, Università degli Studi di Milano, Milan, Italy.
Gaetano BulfamanteDivision of Human Pathology, Department of Health Sciences, Università degli Studi di Milano, Milan, Italy.
Giulia MoraceLaboratory of Microbiology, Department of Health Sciences, Università degli Studi di Milano, Milan, Italy.
Elisa BorghiLaboratory of Microbiology, Department of Health Sciences, Università degli Studi di Milano, Milan, Italy.
University of Milan · ITUniversity of Glasgow · GB

Funding

Biotechnology and Biological Sciences Research Council BB/P504567/1Wellcome Trust 097377/Z/11/Z
6 · The paper itself

Abstract

Acetylcholine modulates the virulence of

Indexed as

Drug RepositioningAnimalsAntifungal AgentsCandida albicansCandidiasisCholinergic AgonistsDisease Models, AnimalImmunologic FactorsLepidopteraPilocarpineReceptors, CholinergicVirulenceAntifungal AgentsCholinergic AgonistsImmunologic FactorsPilocarpineReceptors, CholinergicbiofilmCandida albicansGalleria mellonellamuscarinicpilocarpine hydrochloriderepurposing

Identifiers

PMID30674648
PMCPMC6344604
OpenAlexW2908471540

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.