ArticleNeurology2019
Succinate links atrial dysfunction and cardioembolic stroke.
Article in Neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Plasma Metabolites Link Dietary Patterns to Stroke Risk.Annals of neurology · 2023Trial
- Unveiling the importance of SIRT5 for cardiac health and disease in an era of increasing longevity.GeroScience · 2026Review
- Association of tricarboxylic acid cycle related-metabolites with hypertension in older adults: a community-based cross-sectional study.Journal of human hypertension · 2025Article
- Acetylglutamine Differentially Associated with First-Time Versus Recurrent Stroke.Translational stroke research · 2024Observational
- Body fluid multiomics in 3PM-guided ischemic stroke management: health risk assessment, targeted protection against health-to-disease transition, and cost-effective personalized approach are envisaged.The EPMA journal · 2024Review
- Plasma Metabolites and Life's Simple 7 in REGARDS.Stroke · 2024Article
- Trimethylamine N-Oxide and White Matter Hyperintensity Volume Among Patients With Acute Ischemic Stroke.JAMA network open · 2023Observational
- Gut microbiota-associated metabolites and risk of ischemic stroke in REGARDS.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Association of Circulating Metabolites With Racial Disparities in Hypertension and Stroke in the REGARDS Study.Neurology · 2023Article
- Long-Term Effects of Repeated Blast Exposure in United States Special Operations Forces Personnel: A Pilot Study Protocol.Journal of neurotrauma · 2022Article
- Hypoxanthine is a pharmacodynamic marker of ischemic brain edema modified by glibenclamide.Cell reports. Medicine · 2022Article
- Nucleosides Associated With Incident Ischemic Stroke in the REGARDS and JHS Cohorts.Neurology · 2022Observational
- Comprehensive metabolomic characterization of atrial fibrillation.Frontiers in cardiovascular medicine · 2022Article
- Tricarboxylic acid cycle related-metabolites and risk of atrial fibrillation and heart failure.Metabolism: clinical and experimental · 2021Article
- Ischemic stroke induces cardiac dysfunction and alters transcriptome profile in mice.BMC genomics · 2021Article
- Uric Acid and Gluconic Acid as Predictors of Hyperglycemia and Cytotoxic Injury after Stroke.Translational stroke research · 2021Observational
- The Role of Posttranslational Modification and Mitochondrial Quality Control in Cardiovascular Diseases.Oxidative medicine and cellular longevity · 2021Review
- Promising Biomarker Candidates for Cardioembolic Stroke Etiology. A Brief Narrative Review and Current Opinion.Frontiers in neurology · 2021Review
- Multilevel omics for the discovery of biomarkers and therapeutic targets for stroke.Nature reviews. Neurology · 2020Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo determine whether altered metabolic profiles represent a link between atrial dysfunction and cardioembolic (CE) stroke, and thus whether underlying dysfunctional atrial substrate may contribute to thromboembolism risk in CE stroke.
methodsA total of 144 metabolites were measured using liquid chromatography-tandem mass spectrometry in plasma samples collected within 9 hours of stroke onset in 367 acute stroke patients. Stroke subtype was assigned using the Causative Classification of Stroke System, and CE stroke (n = 181) was compared to non-CE stroke (n = 186). Markers of left atrial dysfunction included abnormal atrial function (P-wave terminal force in lead V1, PTFV
resultsThree tricarboxylic acid metabolites-succinate (odds ratio [OR] 1.71, 95% confidence interval [CI] 1.36-2.15,
conclusionsMetabolite profiling identified changes in succinate associated with CE stroke, atrial dysfunction, and stroke recurrence, revealing a putative underlying link between CE stroke and energy metabolism.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.