Evidence map›Paper›PMID 30674552›Full record

ArticleThe Journal of biological chemistry2019

Epstein-Barr virus miR-BART3-3p promotes tumorigenesis by regulating the senescence pathway in gastric cancer.

Jia Wang, Xiang Zheng, Zailong Qin, Lingyu Wei, Yuanjun Lu, Qiu Peng, Yingxue Gao, Xuemei Zhang, Xiaoyue Zhang, Zhengshuo Li and 8 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. How Oncovirus Affects Drug Resistance in Cancer Cells.Recent patents on anti-cancer drug discovery · 2026
    Review
  3. Viral oncogenesis in cancer: from mechanisms to therapeutics.Signal transduction and targeted therapy · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 3 countries.

Jia WangFrom the Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, China.
Xiang ZhengCancer Research Institute, Department of Microbiology, School of Basic Medical Science, Central South University, Changsha 410078, China.
Zailong QinCancer Research Institute, Department of Microbiology, School of Basic Medical Science, Central South University, Changsha 410078, China.
Lingyu WeiCancer Research Institute, Department of Microbiology, School of Basic Medical Science, Central South University, Changsha 410078, China.
Yuanjun LuCancer Research Institute, Department of Microbiology, School of Basic Medical Science, Central South University, Changsha 410078, China.
Qiu PengCancer Research Institute, Department of Microbiology, School of Basic Medical Science, Central South University, Changsha 410078, China.
Yingxue GaoCancer Research Institute, Department of Microbiology, School of Basic Medical Science, Central South University, Changsha 410078, China.
Xuemei ZhangCancer Research Institute, Department of Microbiology, School of Basic Medical Science, Central South University, Changsha 410078, China.
Xiaoyue ZhangCancer Research Institute, Department of Microbiology, School of Basic Medical Science, Central South University, Changsha 410078, China.
Zhengshuo LiCancer Research Institute, Department of Microbiology, School of Basic Medical Science, Central South University, Changsha 410078, China.
Yuxin FuCancer Research Institute, Department of Microbiology, School of Basic Medical Science, Central South University, Changsha 410078, China.
Peishan LiuCancer Research Institute, Department of Microbiology, School of Basic Medical Science, Central South University, Changsha 410078, China.
Can LiuCancer Research Institute, Department of Microbiology, School of Basic Medical Science, Central South University, Changsha 410078, China.
Qun YanDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Wei XiongCancer Research Institute, Department of Microbiology, School of Basic Medical Science, Central South University, Changsha 410078, China.
Guiyuan LiCancer Research Institute, Department of Microbiology, School of Basic Medical Science, Central South University, Changsha 410078, China.
Jianhong LuCancer Research Institute, Department of Microbiology, School of Basic Medical Science, Central South University, Changsha 410078, China, jianhlu@csu.edu.cn.
Jian MaFrom the Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, China, majian@csu.edu.cn.ORCID 0000-0001-9395-0416
Central South University · CNMinistry of Education of the People's Republic of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epstein-Barr virus-associated gastric cancer (EBVaGC) accounts for about 10% of all gastric cancer cases and has unique pathological and molecular characteristics. EBV encodes a large number of microRNAs, which actively participate in the development of EBV-related tumors. Here, we report that

Indexed as

Cellular SenescenceGene Expression Regulation, NeoplasticGene Expression Regulation, ViralCarcinogenesisCell Line, TumorHerpesvirus 4, HumanHumansMicroRNAsRNA, NeoplasmRNA, ViralStomach NeoplasmsTumor Suppressor Protein p53Viral Matrix ProteinsEBV-associated membrane antigen, Epstein-Barr virusMicroRNAsMIRN-BART3 microRNA, humanRNA, NeoplasmRNA, ViralTP53 protein, humanTumor Suppressor Protein p53Viral Matrix Proteinscellular senescenceDNA virusesEpstein-Barr virusgastric cancermicroRNA (miRNA)miR-BART3–3pp53

Identifiers

PMID30674552
PMCPMC6442059
OpenAlexW2913652739

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.