ArticleCancer research2019
GARP Dampens Cancer Immunity by Sustaining Function and Accumulation of Regulatory T Cells in the Colon.
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Article in Cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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48citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
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Who cites it
48 citing papers in PubMed, 80 citations in OpenAlex.
- Platelets as non-canonical immune regulatory nodes: orchestrating T cell dysfunction and immunotherapy resistance in cancer.Apoptosis : an international journal on programmed cell death · 2026Review
- Higher frequency of circulating regulatory T cells is associated with poor outcomes in patients with colorectal cancer.Discover oncology · 2026Article
- Targeting TGFβ docking receptor glycoprotein A repetitions predominant (GARP) via novel chimeric antigen receptor (CAR)-T cell platform to treat glioblastoma.Neuro-oncology · 2025Article
- Research Progress on the Immune Function of Liver Sinusoidal Endothelial Cells in Sepsis.Cells · 2025Review
- Spatial and single-cell transcriptomics reveal cellular heterogeneity and a novel cancer-promoting Treg cell subset in human clear-cell renal cell carcinoma.Journal for immunotherapy of cancer · 2025Article
- The role of Treg cells in colorectal cancer and the immunotherapy targeting Treg cells.Frontiers in immunology · 2025Review
- Article
- "Decoding inflammation: glycoprotein a repetition predominant, microRNA-142-3-p, and metastasis associated lung adenocarcinoma transcript 1: as novel inflammatory biomarkers of inflammatory bowel disease".Molecular biology reports · 2024Article
- Pathways and molecules for overcoming immunotolerance in metastatic gastrointestinal tumors.Frontiers in immunology · 2024Review
- GARP on hepatic stellate cells is essential for the development of liver fibrosis.Journal of hepatology · 2023Article
- A pairwise immune gene model for predicting overall survival and stratifying subtypes of colon adenocarcinoma.Journal of cancer research and clinical oncology · 2023Article
- Expression patterns and prognostic value of key regulators associated with m7G RNA modification based on all gene expression in colon adenocarcinoma.BMC gastroenterology · 2023Article
- AIM2 and Psoriasis.Frontiers in immunology · 2023Review
- Selective activation of TGFβ signaling byAmerican journal of cancer research · 2023Article
- Changes in circulating TCF1- and GARP-associated regulatory T cell subsets reflect the clinical status of patients with chronic HBV infection.Medical microbiology and immunology · 2022Article
- Selective targeting of GARP-LTGFβ axis in the tumor microenvironment augments PD-1 blockade via enhancing CD8Journal for immunotherapy of cancer · 2022Article
- Mechanisms of chemotherapeutic resistance and the application of targeted nanoparticles for enhanced chemotherapy in colorectal cancer.Journal of nanobiotechnology · 2022Review
- Reduced frequencies of Foxp3Respiratory research · 2022Article
- Translational landscape of glioblastoma immunotherapy for physicians: guiding clinical practice with basic scientific evidence.Journal of hematology & oncology · 2022Review
- Transforming growth factor-β1 in regulatory T cell biology.Science immunology · 2022Review
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Authors and funding
14 authors at 3 institutions in 2 countries.
Mohammad SalemDepartment of Immunology and Microbiology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina.
Caroline WallaceDepartment of Immunology and Microbiology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina.
Maria VelegrakiDepartment of Immunology and Microbiology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina.
Anqi LiDepartment of Immunology and Microbiology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina.
Ephraim Ansa-AddoDepartment of Immunology and Microbiology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina.
Alessandra MetelliDepartment of Immunology and Microbiology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina.
Hyunwoo KwonDepartment of Immunology and Microbiology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina.
Brian RiesenbergDepartment of Immunology and Microbiology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina.
Bill WuDepartment of Immunology and Microbiology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina.
Yongliang ZhangDepartment of Immunology and Microbiology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina.
Silvia GugliettaDepartment of Immunology and Microbiology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina.
Shaoli SunDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina.
Bei LiuDepartment of Immunology and Microbiology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina.
Zihai LiDepartment of Immunology and Microbiology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina. Zihai@musc.edu.
MUSC Hollings Cancer Center · USMedical University of South Carolina · USZhengzhou University · CN
Funding
Project 3: Structural Basis for grp94 Drug Development and Chaperone FunctionP01CA186866 · NCI · OHIO STATE UNIVERSITY · PI LI, ZIHAI · 2015 to 2019
$6.7MRoles and Mechanisms of gp96 in Chaperoning Innate ImmunityR01AI070603 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI LI, ZIHAI · 2007 to 2016
$3.8MMolecular chaperones and immune toleranceR01AI077283 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI LI, ZIHAI · 2009 to 2021
$3.7MExtrinsic and intrinsic factors regulating commensal-specific T helper-17 cellsU01AI125859 · NIAID · OHIO STATE UNIVERSITY · PI LIU, BEI · 2016 to 2020
$2.5MThrombocytes in Cancer ImmunityR01CA188419 · NCI · OHIO STATE UNIVERSITY · PI LI, ZIHAI · 2015 to 2019
$1.9MMechanism of gp96/grp94 in regulating plasma cells and myelomaR01CA193939 · NCI · OHIO STATE UNIVERSITY · PI LIU, BEI · 2016 to 2020
$1.7MIntegration of inflammation and cancer by molecular chaperoneR01CA213290 · NCI · OHIO STATE UNIVERSITY · PI LI, ZIHAI · 2017 to 2021
$860kNCI NIH HHS P01 CA186866NCI NIH HHS R01 CA188419NCI NIH HHS R01 CA193939NCI NIH HHS R01 CA213290NIAID NIH HHS R01 AI070603NIAID NIH HHS R01 AI077283NIAID NIH HHS U01 AI125859
Abstract
Activated regulatory T (Treg) cells express the surface receptor glycoprotein-A repetitions predominant (GARP), which binds and activates latent TGFβ. How GARP modulates Treg function in inflammation and cancer remains unclear. Here we demonstrate that loss of GARP in Treg cells leads to spontaneous inflammation with highly activated CD4
Indexed as
AnimalsApoptosisCD8-Positive T-LymphocytesCell ProliferationColitisColonic NeoplasmsFemaleHumansImmune ToleranceInflammationJurkat CellsMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutSignal TransductionLrrc32 protein, mouseMembrane Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.