Evidence map›Paper›PMID 30674346›Full record

ArticleParasites & vectors2019

Bioabsorption and effectiveness of long-lasting permethrin-treated uniforms over three months among North Carolina outdoor workers.

Kristin M Sullivan, Alison Poffley, Sheana Funkhouser, Jeffrey Driver, John Ross, Maria Ospina, Antonia M Calafat, Charles B Beard, Avian White, Jo Anne Balanay and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parasites & vectors, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Proposed Integrated Control of ZoonoticTropical medicine and infectious disease · 2020
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kristin M SullivanDepartment of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, USA.
Alison PoffleyDepartment of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, USA.
Sheana FunkhouserDepartment of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, USA.
Jeffrey DriverRisksciences LLC, Longboat Key, FL and University of South Florida, College of Public Health, Tampa, FL, USA.
John RossRisksciences LLC, Longboat Key, FL and University of South Florida, College of Public Health, Tampa, FL, USA.
Maria OspinaDivision of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Antonia M CalafatDivision of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Charles B BeardDivision of Vector-borne Diseases, Centers for Disease Control and Prevention, Ft. Collins, CO, USA.
Avian WhiteEnvironmental Health Sciences Program, Department of Health Education and Promotion, East Carolina University, Greenville, NC, USA.
Jo Anne BalanayEnvironmental Health Sciences Program, Department of Health Education and Promotion, East Carolina University, Greenville, NC, USA.
Stephanie RichardsEnvironmental Health Sciences Program, Department of Health Education and Promotion, East Carolina University, Greenville, NC, USA.
Megan DyerCenter for Vector-Borne Disease, University of Rhode Island, Kingston, RI, USA.
Thomas N MatherCenter for Vector-Borne Disease, University of Rhode Island, Kingston, RI, USA.
Steven MeshnickDepartment of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, USA. meshnick@email.unc.edu.

Funding

ACL HHS R01OH010791NIOSH CDC HHS R01 OH010791
6 · The paper itself

Abstract

backgroundVector-borne diseases are an important cause of morbidity and mortality in the USA. Effective, convenient prevention methods are needed. Long-lasting permethrin-impregnated (LLPI) clothing can prevent tick bites, however, additional information is needed on the real-world effectiveness and safety of this preventative measure.

methodsIn this pilot study, we recruited state and county park employees from North Carolina to wear LLPI uniforms for three months during the summer of 2016. We collected spot urine samples for biomonitoring of permethrin metabolites at one week, one month and three months after first use of the LLPI uniform. Following three months of wear, we collected pants and socks and analyzed them for permethrin content and mortality to ticks and mosquitoes.

resultsThirteen park employees were included in the analysis. Bioactive amounts of permethrin remained in all clothing swatches tested, although there was great variability. Tick mortality was high, with 78% of pant and 88% of sock swatches having mean knockdown percentages ≥ 85%. In contrast, mosquito mortality was low. Over the study period, the absorbed dosage of permethrin averaged < 4 μg/kg/d of body weight based on measurements of three metabolites.

conclusionsLLPI clothing retained permethrin and bioactivity against ticks after three months of use in real-world conditions. The estimated absorbed dosage of permethrin was well below the U.S. EPA level of concern, suggesting that LLPI clothing can be used safely by outdoor workers for tick bite prevention.

Indexed as

ClothingAdsorptionAnimalsBites and StingsCulicidaeHumansInsecticidesInsect RepellentsMosquito VectorsNorth CarolinaPermethrinPilot ProjectsTick BitesTicksInsecticidesInsect RepellentsPermethrinMosquitoesPermethrinPermethrin absorptionPermethrin treatmentRepellentTick bitesTicks

Identifiers

PMID30674346
PMCPMC6343280

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.