Evidence map›Paper›PMID 30674155›Full record

ArticleGels (Basel, Switzerland)2016

Polyelectrolyte Hydrogel Platforms for the Delivery of Antidepressant Drugs.

Mario Casolaro, Ilaria Casolaro

Open access · goldAbstract read
In one paragraph

Article in Gels (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Transforming Treatment: The Impact of Bariatric Surgery on Oral Drug Absorption.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
    Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Sciatic nerve regeneration by using collagen type I hydrogel containing naringin.Journal of materials science. Materials in medicine · 2019
    Article
  7. Article
  8. Properties of Water Bound in Hydrogels.Gels (Basel, Switzerland) · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Mario CasolaroDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, Siena 53100, Italy. mario.casolaro@unisi.it.
Ilaria CasolaroPsychiatry Resident, University of Siena, Siena 53100, Italy. casolaro.ilaria@gmail.com.
University of Siena · IT

Funding

Siena University
6 · The paper itself

Abstract

Some vinyl hydrogels containing α-amino acid residues (l-phenylalanine, l-valine) were used as polyelectrolyte platforms for the evaluation of the controlled release of two antidepressants (paroxetine and duloxetine). The closer acidity constant (pKa) values of the two drugs show a closer release profile in physiological phosphate buffered saline (PBS) buffer (pH 7.40) and for long periods of time. The great electrostatic interaction forces between the COO

Indexed as

duloxetineparoxetinepolyelectrolytespulsatile drug releasestimuli-responsive hydrogels

Identifiers

PMID30674155
PMCPMC6318638
OpenAlexW2524954732

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.