ReviewGels (Basel, Switzerland)2016
Combinatorial Method/High Throughput Strategies for Hydrogel Optimization in Tissue Engineering Applications.
Review in Gels (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Design and Fabrication of Biomimetic Gradient Bone Tissue Engineering Scaffolds: Evolution from Single-Gradient to Multi-Gradient.Gels (Basel, Switzerland) · 2026Review
- Scalable Accelerated Materials Discovery of Sustainable Polysaccharide-Based Hydrogels by Autonomous Experimentation and Collaborative Learning.ACS applied materials & interfaces · 2024Article
- Statistical optimization of cell-hydrogel interactions for green microbiology - a tutorial review.RSC sustainability · 2024Review
- Gradient Material Strategies for Hydrogel Optimization in Tissue Engineering Applications.High-throughput · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Combinatorial method/high throughput strategies, which have long been used in the pharmaceutical industry, have recently been applied to hydrogel optimization for tissue engineering applications. Although many combinatorial methods have been developed, few are suitable for use in tissue engineering hydrogel optimization. Currently, only three approaches (design of experiment, arrays and continuous gradients) have been utilized. This review highlights recent work with each approach. The benefits and disadvantages of design of experiment, array and continuous gradient approaches depending on study objectives and the general advantages of using combinatorial methods for hydrogel optimization over traditional optimization strategies will be discussed. Fabrication considerations for combinatorial method/high throughput samples will additionally be addressed to provide an assessment of the current state of the field, and potential future contributions to expedited material optimization and design.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.