Evidence map›Paper›PMID 30674078›Full record

SynthesisJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2019

Change in Bone Density and Reduction in Fracture Risk: A Meta-Regression of Published Trials.

Mary L Bouxsein, Richard Eastell, Li-Yung Lui, Lucy A Wu, Anne E de Papp, Andreas Grauer, Fernando Marin, Jane A Cauley, Douglas C Bauer, Dennis M Black and 1 more

Registry-linked trialOpen access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05613400 (The Effect of Simvastatin on Bone Density in Postmenopausal Women With Type 2 Diabetes), which is not on this map. Cited by 183 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
183citing papers in PubMed, 19 pooled it
31.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05613400 phase4unknown statusstarted 2022, after this paper: background citation

The Effect of Simvastatin on Bone Density in Postmenopausal Women With Type 2 Diabetes: a Double-blind, Randomized Active-comparator (Ezetimibe) Controlled Clinical Trial

Ran2022Enrolled240Registered outcomes7Posted comparisons0ConditionsDiabetes Mellitus, Type 2ArmsEzetimibe 10mg, Simvastatin 10mg
PMID 28434032PMID 10720052PMID 15317608PMID 17530471PMID 26969416PMID 27004165PMID 29496507PMID 30066131PMID 30403505PMID 30615801PMID 11701680PMID 31384961other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

183 citing papers in PubMed, 19 syntheses or guidelines pooled it, 336 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. A systematic review and meta-analysis of sequential treatment strategies for osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Pooled it
  4. Bone mineral content among Inuit - a systematic review of data.International journal of circumpolar health · 2025
    Pooled it
  5. Pooled it
  6. Risk factors for refracture or new vertebral compression fractures after percutaneous vertebroplasty: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Pooled it
  7. Pooled it
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  12. Clinical practice guideline for management of osteoporosis and fracture prevention in Canada: 2023 update.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2023
    Guideline
  13. Pooled it
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  15. A systematic review of cost‑effectiveness analyses of sequential treatment for osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023
    Pooled it
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  18. Effects of non-supervised exercise interventions on bone mineral density in adult women: a systematic review and meta‑analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022
    Pooled it
  19. Pooled it
  20. Trial

123 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 3 countries.

Mary L BouxseinCenter for Advanced Orthopedic Studies, Department of Orthopedic Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Richard EastellAcademic Unit of Bone Metabolism, University of Sheffield, Sheffield, UK.
Li-Yung LuiCalifornia Pacific Medical Center, San Francisco, CA, USA.
Lucy A WuDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
Anne E de PappMerck & Co., Inc., Kenilworth, NJ, USA.
Andreas GrauerAmgen Inc., Thousand Oaks, CA, USA.
Fernando MarinEli Lilly and Company, Lilly Research Centre, Windlesham, UK.
Jane A CauleyDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Douglas C BauerDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
Dennis M BlackDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
FNIH Bone Quality ProjectDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
University of California, San Francisco · USAmgen (United States) · USBeth Israel Deaconess Medical Center · USCalifornia Pacific Medical Center · USEli Lilly (United States) · USMerck & Co., Inc., Rahway, NJ, USA (United States) · USUniversidade São Francisco · BRUniversity of Pittsburgh · USUniversity of Sheffield · GB

Funding

FNIH Bone Quality ProjectMedical Research Council MR/K006312/1Medical Research Council MR/P020941/1
6 · The paper itself

Abstract

Meta-analyses conducted >15 years ago reported that improvements in bone mineral density (BMD) were associated with reduction in vertebral and nonvertebral fractures in osteoporosis trials. Numerous studies have been conducted since then, incorporating new therapies with different mechanisms of action and enrolling many more subjects. To extend these prior analyses, we conducted a meta-regression of 38 placebo-controlled trials of 19 therapeutic agents to determine the association between improvements in BMD and reductions in fracture risk. We used a linear model to examine the relationship between mean percent difference in BMD change between treatment and placebo groups and the logarithm of the relative risk. We found that greater improvements in BMD were strongly associated with greater reductions in vertebral and hip fractures but not nonvertebral fractures. For vertebral fracture, the r

Indexed as

Absorptiometry, PhotonBone DensityHip FracturesOsteoporosisOsteoporotic FracturesSpinal FracturesHumansRandomized Controlled Trials as TopicRisk FactorsBONE MINERAL DENSITYCLINICAL TRIALMETA-REGRESSIONOSTEOPOROSISSURROGATE

Identifiers

PMID30674078
OpenAlexW2912416377

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.