Evidence map›Paper›PMID 30674062›Full record

ArticleJournal of neurochemistry2019

Effects of HIV-1 Tat on oligodendrocyte viability are mediated by CaMKIIβ-GSK3β interactions.

Shiping Zou, Joyce M Balinang, Jason J Paris, Kurt F Hauser, Babette Fuss, Pamela E Knapp

Open access · bronzeAbstract read
In one paragraph

Article in Journal of neurochemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
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  16. Functional impact of HIV-1 Tat on cells of the CNS and its role in HAND.Cellular and molecular life sciences : CMLS · 2020
    Review
  17. Opioid and neuroHIV Comorbidity - Current and Future Perspectives.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020
    Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Shiping ZouDepartment of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Joyce M BalinangDepartment of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Jason J ParisDepartment of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Kurt F HauserDepartment of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Babette FussDepartment of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Pamela E KnappDepartment of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.ORCID 0000-0003-4364-6074
Virginia Commonwealth University · US

Funding

VCU Neuroscience Center Core GrantP30NS047463 · NINDS · VIRGINIA COMMONWEALTH UNIVERSITY · PI POVLISHOCK, JOHN T · 2003 to 2013
$5.0M
Glial Progenitors as Targets of HIV/Opiate InteractionsR01DA024461 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI KNAPP, PAMELA E · 2007 to 2018
$3.9M
HIV opiate interactions in white matter pathologyR01DA044939 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI HAUSER, KURT F, KNAPP, PAMELA E · 2017 to 2021
$2.7M
Neuron-Glia Mechanisms & Interactions Underlying Opioid Abuse-HIV-1 ComorbidityK02DA027374 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI HAUSER, KURT F · 2009 to 2018
$1.3M
CaMKIIbeta: a regulator of CNS myelinationR21NS084335 · NINDS · VIRGINIA COMMONWEALTH UNIVERSITY · PI FUSS, BABETTE · 2014 to 2015
$419k
HIV-1 disrupts oligodendrocyte functions: Ca2+ mediated mechanismsF31NS084838 · NINDS · VIRGINIA COMMONWEALTH UNIVERSITY · PI ZOU, SHIPING · 2014 to 2015
$65k
NIDA NIH HHS K02 DA027374NIDA NIH HHS R01 DA024461NIDA NIH HHS R01 DA044939NINDS NIH HHS F31 NS084838NINDS NIH HHS P30 NS047463NINDS NIH HHS R21 NS084335
6 · The paper itself

Abstract

Myelin disruptions are frequently reported in human immunodeficiency virus (HIV)-infected individuals and can occur in the CNS very early in the disease process. Immature oligodendrocytes (OLs) are quite sensitive to toxic increases in [Ca

Indexed as

AnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2Cell SurvivalGlycogen Synthase Kinase 3 betaHIV-1HIV InfectionsMiceMice, TransgenicOligodendrogliatat Gene Products, Human Immunodeficiency VirusCalcium-Calmodulin-Dependent Protein Kinase Type 2Glycogen Synthase Kinase 3 betaGsk3b protein, mousetat Gene Products, Human Immunodeficiency Viruscalciumcell deathcortexhippocampusmyelinationneuroAIDSstriatum

Identifiers

PMID30674062
PMCPMC6438763
OpenAlexW2912629617

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.