Evidence map›Paper›PMID 30674050›Full record

ArticleAmerican journal of perinatology2019

A Genome-Wide Analysis of Clinical Chorioamnionitis among Preterm Infants.

Ariana M Spiegel, Jingjing Li, John W Oehlert, Jonathan A Mayo, Cecele C Quaintance, Anna I Girsen, Maurice L Druzin, Yasser Y El-Sayed, Gary M Shaw, David K Stevenson and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of perinatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Management of clinical chorioamnionitis: an evidence-based approach.American journal of obstetrics and gynecology · 2020
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Ariana M SpiegelDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California.
Jingjing LiDivision of Neonatal and Developmental Medicine, Department of Pediatrics, March of Dimes Prematurity Research Center at Stanford University, Stanford University School of Medicine, Stanford, California.
John W OehlertDivision of Neonatal and Developmental Medicine, Department of Pediatrics, March of Dimes Prematurity Research Center at Stanford University, Stanford University School of Medicine, Stanford, California.
Jonathan A MayoDivision of Neonatal and Developmental Medicine, Department of Pediatrics, March of Dimes Prematurity Research Center at Stanford University, Stanford University School of Medicine, Stanford, California.
Cecele C QuaintanceDivision of Neonatal and Developmental Medicine, Department of Pediatrics, March of Dimes Prematurity Research Center at Stanford University, Stanford University School of Medicine, Stanford, California.
Anna I GirsenDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California.
Maurice L DruzinDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California.
Yasser Y El-SayedDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California.
Gary M ShawDivision of Neonatal and Developmental Medicine, Department of Pediatrics, March of Dimes Prematurity Research Center at Stanford University, Stanford University School of Medicine, Stanford, California.
David K StevensonDivision of Neonatal and Developmental Medicine, Department of Pediatrics, March of Dimes Prematurity Research Center at Stanford University, Stanford University School of Medicine, Stanford, California.
Ronald S GibbsDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California.
Stanford University · USMarch of Dimes · US

Funding

Genomic Influences on Bronchopulmonary Dysplasia-A Population-Based StudyRC2HL101748 · NHLBI · STANFORD UNIVERSITY · PI OBRODOVICH, HUGH · 2009 to 2010
$3.5M
NHLBI NIH HHS RC2 HL101748
6 · The paper itself

Abstract

objectiveTo identify single nucleotide polymorphisms (SNPs) associated with clinical chorioamnionitis among preterm infants. STUDY

designWe reanalyzed a genome-wide association study (GWAS) from preterm newborns at less than 30 weeks' gestation. Cases and control definitions were determined using administrative records. There were 213 clinical chorioamnionitis cases and 707 clinically uninfected controls. We compared demographic and clinical outcomes of cases and controls. We performed a GWAS and compared the distribution of SNPs from the background genes and from the immunome genes. We used a Wilcoxon's rank-sum test to compare the SNPs normalized odds ratio and used odds ratios and

resultsInfants affected by clinical chorioamnionitis were more likely to have periventricular leukomalacia, high-grade retinopathy, and high-grade intraventricular hemorrhage (IVH). Although a GWAS did not identify SNPs associated with clinical chorioamnionitis at the genome-wide significance level, a direct test on the exonic variants in the human immunome revealed their significant increase of risk in clinical chorioamnionitis.

conclusionAmong very preterm infants, clinical chorioamnionitis was associated with periventricular leukomalacia, high-grade retinopathy, and IVH. Our analysis of variants in the human immunome indicates an association with clinical chorioamnionitis in very preterm pregnancies.

Indexed as

Genetic Predisposition to DiseaseInfant, PrematurePolymorphism, Single NucleotideAdultCase-Control StudiesCerebral Intraventricular HemorrhageChorioamnionitisFemaleGenome-Wide Association StudyHumansImmunityInfant, NewbornInfant, Premature, DiseasesLeukomalacia, PeriventricularMalePregnancy

Identifiers

PMID30674050
PMCPMC11182631
OpenAlexW2913020099

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.