Evidence map›Paper›PMID 30674011›Full record

ArticleJournal of endocrinological investigation2019

Alterations in the intestinal microbiota of patients with severe and active Graves' orbitopathy: a cross-sectional study.

T-T Shi, Z Xin, L Hua, R-X Zhao, Y-L Yang, H Wang, S Zhang, W Liu, R-R Xie

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In one paragraph

Article in Journal of endocrinological investigation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 6 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 6 syntheses or guidelines pooled it, 71 citations in OpenAlex.

  1. Pooled it
  2. Changes in Gut Microbiota and Multiple Sclerosis: A Systematic Review.International journal of environmental research and public health · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

T-T ShiDepartment of Endocrinology, Beijing Tongren Hospital, Capital Medical University, 1 Dong Jiao Min Xiang, Beijing, 100730, China.
Z XinDepartment of Endocrinology, Beijing Tongren Hospital, Capital Medical University, 1 Dong Jiao Min Xiang, Beijing, 100730, China. xinz@medmail.com.cn.ORCID http://orcid.org/0000-0002-6840-1922
L HuaDepartment of Mathematics, School of Biomedical Engineering, Capital Medical University, Beijing, 100069, China. hualin7750@139.com.
R-X ZhaoDepartment of Endocrinology, Beijing Tongren Hospital, Capital Medical University, 1 Dong Jiao Min Xiang, Beijing, 100730, China.
Y-L YangDepartment of Endocrinology, Beijing Tongren Hospital, Capital Medical University, 1 Dong Jiao Min Xiang, Beijing, 100730, China.
H WangDepartment of Emergency, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
S ZhangDepartment of Pharmacy, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
W LiuDepartment of Endocrinology, Beijing Tongren Hospital, Capital Medical University, 1 Dong Jiao Min Xiang, Beijing, 100730, China.
R-R XieDepartment of Endocrinology, Beijing Tongren Hospital, Capital Medical University, 1 Dong Jiao Min Xiang, Beijing, 100730, China.
Beijing Tongren Hospital · CNCapital Medical University · CN

Funding

The Beijing Municipal Hospital Research and Development Program PX2016063The Expert Promotion Program of Beijing Health Systems 2015-3-017The Foundation of Beijing Tongren Hospital 2015-YJJ-ZZL-006
6 · The paper itself

Abstract

backgroundThe intestinal microbiota was linked to autoimmune diseases. Graves' orbitopathy (GO) is an autoimmune disease that is usually associated with Graves' disease. However, information on the microbiome of GO patients is yet lacking.

objectivesTo investigate whether GO patients differ from healthy controls in the fecal microbiota.

designA cross-sectional study.

setting33 patients with severe and active GO and 32 healthy controls of Han nationality were enrolled between March 2017 and March 2018.

methodsThe Gut microbial communities of the fecal samples of GO patients and healthy controls were analyzed and compared by 16S rRNA gene sequencing.

resultsCommunity diversity (Simpson and Shannon) was significantly reduced in fecal samples from patients with GO as compared to controls (p < 0.05). The similarity observed while assessing the community diversity (PCoA) proposed that the microbiota of patients with GO differ significantly from those of controls (p < 0.05). At the phyla levels, the proportion of Bacteroidetes increased significantly in patients with GO (p < 0.05), while at the genus and species levels, significant differences were observed in the bacterial profiles between the two groups (p < 0.05). LIMITATIONS: Single-centered study design and limited fecal samples.

conclusionsThe present study indicated distinctive features of the gut microbiota in GO patients. The study provided evidence for further exploration in the field of intestinal microbiota with respect to the diagnosis and treatment of GO patients by modifying the microbiota profile.

Indexed as

AdolescentAdultAgedAutoantibodiesBiomarkersCase-Control StudiesCohort StudiesCross-Sectional StudiesFecesFemaleFollow-Up StudiesGastrointestinal MicrobiomeGraves OphthalmopathyHumansMaleMiddle AgedAutoantibodiesBiomarkersRNA, Ribosomal, 16S16S rRNA geneGraves’ orbitopathy (GO)Gut microbiotaThyrotropin receptor antibody (TRAb)

Identifiers

PMID30674011
OpenAlexW2913514276

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.