ArticleMikrochimica acta2019
Colorimetric and fluorometric dual-channel detection of α-fetoprotein based on the use of ZnS-CdTe hierarchical porous nanospheres.
Article in Mikrochimica acta, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Tungsten Oxide-Mediated Photocatalytic Silver Enhancement in a QCM Immunosensor for Alpha-Fetoprotein Detection.Biosensors · 2025Article
- Fluorescent-Electrochemical-Colorimetric Triple-Model Immunoassays with Multifunctional Metal-Organic Frameworks for Signal Amplification.Biosensors · 2025Article
- Overview of the Design and Application of Dual-Signal Immunoassays.Molecules (Basel, Switzerland) · 2024Review
- Biosensing of Alpha-Fetoprotein: A Key Direction toward the Early Detection and Management of Hepatocellular Carcinoma.Biosensors · 2024Review
- Application of Metal-Based Nanomaterials in In Vitro Diagnosis of Tumor Markers: Summary and Prospect.Molecules (Basel, Switzerland) · 2023Review
- Metal Nanoparticles/MoSACS applied materials & interfaces · 2021Article
- Oriented boronate affinity-imprinted inverse opal hydrogel for glycoprotein assay via colorimetry.Mikrochimica acta · 2020Article
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Authors and funding
5 authors.
Funding
Abstract
An immunoassay is described for either colorimetric and fluorometric determination of the cancer biomarker α-fetoprotein (AFP). It is making use of ZnS nanospheres modified with CdTe quantum dots (QDs). These display strong fluorescence due to the enrichment of the QDs onto the porous ZnS nanospheres. In this assay, the release of millions of zinc(II) ions can be triggered to form a purple complex (with an absorption maximum at 571 nm) on addition of the reagent 2-(5-nitro-2-pyridylazo)-5-(N-propyl-N-sulfopropylamino) phenol. This results in a sensitive colorimetric immunoassay which can also be used as a visual test. It represents an enzyme-free alternative to the commonly used ELISAs. It also can be evaluated by fluorometry (with excitation/emission maxima at 400/645 nm). The detection limits are 10 pg·mL
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