ReviewThe New England journal of medicine2019
Opioid Tolerance in Critical Illness.
Review in The New England journal of medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
98 citing papers in PubMed, 3 syntheses or guidelines pooled it, 207 citations in OpenAlex.
- Prevalence and incidence of ICU delirium and pain: a systematic review and meta-analysis.Intensive care medicine · 2025Pooled it
- The association between pain, analgesia, and delirium among critically ill adults: a systematic review and meta-analysis.Intensive care medicine · 2025Pooled it
- Methadone for critically ill patients under mechanical ventilation in the intensive care unit: a systematic review.Critical care science · 2025Pooled it
- Effect of Ultrasound-Guided Sciatic and Saphenous Nerve Blocks on Analgesia During General Anaesthesia for Ankle Fracture Surgery: A Randomised Controlled Trial.Medicina (Kaunas, Lithuania) · 2026Trial
- The effects of aromatherapy and music on pain, anxiety, and stress levels in palliative care patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Trial
- Acute Pain During Intensive Care: Prevalence, Predisposing Factors and Pain Trajectories. A Prospective Multicenter Observational Study.Acta anaesthesiologica Scandinavica · 2026Observational
- Individualizing Perioperative Analgesia: Patient-Specific Determinants of Postoperative Pain and Opioid-Related Outcomes.Medicina (Kaunas, Lithuania) · 2026Review
- Opioids to Treat Chronic Pain in the Older Adult: A Clinical Consensus to Guarantee Safety and Avoid Adverse Events.Drugs & aging · 2026Review
- Hydromorphone in Pediatric Pain Management: Pharmacology, Clinical Applications, and Safety Considerations-A Narrative Review.Healthcare (Basel, Switzerland) · 2026Review
- Molecular mechanism of allosteric modulation of opioid receptors.Signal transduction and targeted therapy · 2026Article
- Functional Outcomes After Hip Arthroscopy Based on Self-Reported Cannabis Use: A Matched-Controlled Study.Orthopaedic journal of sports medicine · 2026Article
- Analgesia and sedation trends in a level IV NICU, 2014-2024: Opioid and dexmedetomidine use.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Changes in perineuronal net and parvalbumin expression in the orbitofrontal cortex of male Wistar rats following repeated fentanyl administration.bioRxiv : the preprint server for biology · 2026Article
- Optimizing Opioid Use in Pain Management: A Comprehensive Review of Clinical Benefits, Risks, and Dependence.Healthcare (Basel, Switzerland) · 2026Review
- GCell research · 2026Article
- Strategies for a Rational Use of Opioids in Critical Care Settings.Journal of clinical medicine · 2026Review
- Postoperative Pain and Opioid Use Following Lower-Limb Escharectomy and Skin Grafting Under a Standardized Regional Anesthesia Protocol: A Retrospective Study.Life (Basel, Switzerland) · 2026Article
- Changes in perineuronal net and parvalbumin expression in the orbitofrontal cortex of male Wistar rats following repeated fentanyl administration.Frontiers in neuroscience · 2026Article
- Targeting the oxidative stress-neuroinflammation axis: the mechanism of arctigenin's broad-spectrum analgesia with limited side effects.Frontiers in immunology · 2026Article
- Transcutaneous Electrical Acupoint Stimulation for Opioid Tolerance in Hepatocellular Carcinoma and Proteomics Analysis: A Randomized Controlled Trial Protocol.Journal of pain research · 2026Article
38 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
PubMed holds no abstract for this paper.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.