ArticleJournal of the American Chemical Society2019
Hydrocarbon Synthesis via Photoenzymatic Decarboxylation of Carboxylic Acids.
Article in Journal of the American Chemical Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 167 citations in OpenAlex.
- Molecular Mechanism of the Catalytic Radical Termination in Fatty Acid Photodecarboxylase.Journal of the American Chemical Society · 2026Article
- Structural Principles of Covalent Flavin Modification in Oxidoreductases.Biochemistry · 2026Review
- Establishing the Fatty Acid PhotodecarboxylaseACS catalysis · 2026Article
- Designing and Engineering Enzymes for New-to-Nature Photobiocatalysis.Methods in molecular biology (Clifton, N.J.) · 2026Review
- Photoenzymatic Decarboxylation to Produce Hydrocarbon Fuels: A Critical Review.Molecular biotechnology · 2025Review
- Transitioning enzyme catalysis towards photocatalysis.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025Review
- Article
- Cavity-Based Discovery of New Fatty Acid Photodecarboxylases.Chembiochem : a European journal of chemical biology · 2024Article
- Decarboxylation in Natural Products Biosynthesis.JACS Au · 2024Review
- Stereodivergent photobiocatalytic radical cyclization through the repurposing and directed evolution of fatty acid photodecarboxylases.Nature chemistry · 2024Article
- Photocatalytic Transformation of Biomass and Biomass Derived Compounds-Application to Organic Synthesis.Molecules (Basel, Switzerland) · 2023Review
- Cell-free metabolic engineering enables selective biotransformation of fatty acids to value-added chemicals.Metabolic engineering communications · 2023Article
- Photobiocatalytic Strategies for Organic Synthesis.Chemical reviews · 2023Review
- Autocatalytic effect boosts the production of medium-chain hydrocarbons by fatty acid photodecarboxylase.Science advances · 2023Article
- Ultrafast Dynamics and Catalytic Mechanism of Fatty Acid Photodecarboxylase.Angewandte Chemie (International ed. in English) · 2022Article
- Versatile Applications of Cyanobacteria in Biotechnology.Microorganisms · 2022Review
- Strategies for Transferring Photobiocatalysis to Continuous Flow Exemplified by Photodecarboxylation of Fatty Acids.ACS catalysis · 2022Article
- Photoinduced Covalent Irreversible Inactivation of Proline Dehydrogenase by S-Heterocycles.ACS chemical biology · 2021Article
- Stabilisation of the Fatty Acid Decarboxylase from Chlorella variabilis by Caprylic Acid.Chembiochem : a European journal of chemical biology · 2021Article
- Light-driven decarboxylative deuteration enabled by a divergently engineered photodecarboxylase.Nature communications · 2021Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A recently discovered photodecarboxylase from Chlorella variabilis NC64A ( CvFAP) bears the promise for the efficient and selective synthesis of hydrocarbons from carboxylic acids. CvFAP, however, exhibits a clear preference for long-chain fatty acids thereby limiting its broad applicability. In this contribution, we demonstrate that the decoy molecule approach enables conversion of a broad range of carboxylic acids by filling up the vacant substrate access channel of the photodecarboxylase. These results not only demonstrate a practical application of a unique, photoactivated enzyme but also pave the way to selective production of short-chain alkanes from waste carboxylic acids under mild reaction conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.