Evidence map›Paper›PMID 30673213›Full record

ArticleACS nano2019

Deciphering the Rules for Amino Acid Co-Assembly Based on Interlayer Distances.

Santu Bera, Sudipta Mondal, Yiming Tang, Guy Jacoby, Elad Arad, Tom Guterman, Raz Jelinek, Roy Beck, Guanghong Wei, Ehud Gazit

Open access · greenAbstract read
In one paragraph

Article in ACS nano, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.7field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Topology in Biological Piezoelectric Materials.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
  4. Article
  5. Review
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  7. Assessment of the MARTINI 3 Performance for Short Peptide Self-Assembly.Journal of chemical theory and computation · 2024
    Article
  8. Article
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  10. Article
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  12. Article
  13. Review
  14. Article
  15. Article
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  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Santu BeraDepartment of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences , Tel Aviv University , Tel Aviv 69978 , Israel.ORCID 0000-0002-4830-552X
Sudipta MondalDepartment of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences , Tel Aviv University , Tel Aviv 69978 , Israel.ORCID 0000-0002-1146-8659
Yiming TangDepartment of Physics, State Key Laboratory of Surface Physics, Key Laboratory for Computational Physical Sciences (MOE) , Fudan University , Shanghai 200433 , People's Republic of China.
Guy JacobyThe Raymond and Beverly Sackler School of Physics and Astronomy , Tel Aviv University , Tel Aviv 69978 , Israel.
Elad AradDepartment of Chemistry, Ilse Katz Institute (IKI) for Nanoscale Science and Technology , Ben Gurion University of the Negev , Beer Sheva 8410501 , Israel.
Tom GutermanDepartment of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences , Tel Aviv University , Tel Aviv 69978 , Israel.
Raz JelinekDepartment of Chemistry, Ilse Katz Institute (IKI) for Nanoscale Science and Technology , Ben Gurion University of the Negev , Beer Sheva 8410501 , Israel.ORCID 0000-0002-0336-1384
Roy BeckThe Raymond and Beverly Sackler School of Physics and Astronomy , Tel Aviv University , Tel Aviv 69978 , Israel.ORCID 0000-0003-3121-4530
Guanghong WeiDepartment of Physics, State Key Laboratory of Surface Physics, Key Laboratory for Computational Physical Sciences (MOE) , Fudan University , Shanghai 200433 , People's Republic of China.ORCID 0000-0001-5814-3328
Ehud GazitDepartment of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences , Tel Aviv University , Tel Aviv 69978 , Israel.ORCID 0000-0001-5764-1720
Tel Aviv University · ILBen-Gurion University of the Negev · ILFudan University · CN

Funding

European Research Council 694426
6 · The paper itself

Abstract

Metabolite materials are extremely useful to obtain functional bioinspired assemblies with unique physical properties for various applications in the fields of material science, engineering, and medicine by self-assembly of the simplest biological building blocks. Supramolecular co-assembly has recently emerged as a promising extended approach to further expand the conformational space of metabolite assemblies in terms of structural and functional complexity. Yet, the design of synergistically co-assembled amino acids to produce tailor-made functional architectures is still challenging. Herein, we propose a design rule to predict the supramolecular co-assembly of naturally occurring amino acids based on their interlayer separation distances observed in single crystals. Using diverse experimental techniques, we demonstrate that amino acids with comparable interlayer separation strongly interact and co-assemble to produce structural composites distinctly different from their individual properties. However, such an interaction is hampered in a mixture of differentially layer-separated amino acids, which self-sort to generate individual characteristic structures. This study provides a different paradigm for the modular design of supramolecular assemblies based on amino acids with predictable properties.

Indexed as

Amino AcidsMass SpectrometryMicroscopy, Electron, ScanningMolecular Dynamics SimulationNanostructuresPeptidesAmino AcidsPeptidesamino acidco-assemblycomposite biomaterialsinterlayer distancesupramolecular β-sheet

Identifiers

PMID30673213
PMCPMC7616932
OpenAlexW2914488206

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.