ArticleACS nano2019
Residue-Specific Solvation-Directed Thermodynamic and Kinetic Control over Peptide Self-Assembly with 1D/2D Structure Selection.
Article in ACS nano, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Molecular Design in l-Glutamic Acid-Based Peptide Assembly Dynamics Driven by Carbodiimide-Fueled Reaction Cycle.Biomacromolecules · 2026Article
- 2D Assemblies Based on a Tetraphenylethylene D,L-Cyclic Peptide Scaffold.Angewandte Chemie (International ed. in English) · 2025Article
- Complex Donuts: Small Variations in DNA Sequence Dictate Pathway Complexity in DNA Nanotoroids.Angewandte Chemie (International ed. in English) · 2025Article
- Understanding multicomponent low molecular weight gels from gelators to networks.Journal of advanced research · 2025Review
- 3,4-Ethylenedioxythiophene Hydrogels: Relating Structure and Charge Transport in Supramolecular Gels.Chemistry of materials : a publication of the American Chemical Society · 2024Article
- Particle Engineering via Supramolecular Assembly of Macroscopic Hydrophobic Building Blocks.Angewandte Chemie (International ed. in English) · 2024Article
- Self-assembly of cyclic peptide monolayers by hydrophobic supramolecular hinges.Chemical science · 2023Article
- Bioinspired Tumor-Targeting and Biomarker-Activatable Cell-Material Interfacing System Enhances Osteosarcoma Treatment via Biomineralization.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Multistep, site-selective noncovalent synthesis of two-dimensional block supramolecular polymers.Nature chemistry · 2023Article
- Lipidation Alters the Structure and Hydration of Myristoylated Intrinsically Disordered Proteins.Biomacromolecules · 2023Article
- Ionic supramolecular polymerization of water-soluble porphyrins: balancing ionic attraction and steric repulsion to govern stacking.RSC advances · 2022Article
- Collagen-Binding Peptide-Enabled Supramolecular Hydrogel Design for Improved Organ Adhesion and Sprayable Therapeutic Delivery.Nano letters · 2022Article
- Molecular Engineering of Peptide-Drug Conjugates for Therapeutics.Pharmaceutics · 2022Review
- Alcohol-perturbed self-assembly of the tobacco mosaic virus coat protein.Beilstein journal of nanotechnology · 2022Article
- Robust and Versatile Coatings Engineered via Simultaneous Covalent and Noncovalent Interactions.Angewandte Chemie (International ed. in English) · 2021Article
- Pathogen-specific antimicrobials engineered de novo through membrane-protein biomimicry.Nature biomedical engineering · 2021Article
- Fluorinated peptide biomaterials.Peptide science (Hoboken, N.J.) · 2021Article
- Solute-Solvent Interactions in Modern Physical Organic Chemistry: Supramolecular Polymers as a Muse.Journal of the American Chemical Society · 2020Article
- A combined experimental and computational approach reveals how aromatic peptide amphiphiles self-assemble to form ion-conducting nanohelices.Materials chemistry frontiers · 2020Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Understanding the self-organization and structural transformations of molecular ensembles is important to explore the complexity of biological systems. Here, we illustrate the crucial role of cosolvents and solvation effects in thermodynamic and kinetic control over peptide association into ultrathin Janus nanosheets, elongated nanobelts, and amyloid-like fibrils. We gained further insight into the solvation-directed self-assembly (SDSA) by investigating residue-specific peptide solvation using molecular dynamics modeling. We proposed the preferential solvation of the aromatic and alkyl domains on the peptide backbone and protofibril surface, which results in volume exclusion effects and restricts the peptide association between hydrophobic walls. We explored the SDSA phenomenon in a library of cosolvents (protic and aprotic), where less polar cosolvents were found to exert a stronger influence on the energetic balance at play during peptide propagation. By tailoring cosolvent polarity, we were able to achieve precise control of the peptide nanostructures with 1D/2D shape selection. We also illustrated the complexity of the SDSA system with pathway-dependent peptide aggregation, where two self-assembly states ( i.e., thermodynamic equilibrium state and kinetically trapped state) from different sample preparation methods were obtained.
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Registered trials
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