ArticleThe Journal of physiology2019
Motor units as tools to evaluate profile of human Renshaw inhibition.
Article in The Journal of physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed.
- Probabilistic inference of homonymous and heteronymous recurrent inhibition in human muscles from large-scale motor neuron recordings.Science advances · 2026Article
- Proximo-distal gradient of spinal recurrent inhibition: implications for motor pool fractionation and dexterity.Experimental brain research · 2026Article
- Article
- The variability of reflex amplitude estimates in motor unit pools depends on the phenotype distribution and discharge statistics.bioRxiv : the preprint server for biology · 2026Article
- Personalized mapping of inhibitory spinal cord circuits in humans via noninvasive neural decoding and in silico modeling.Science advances · 2025Article
- On the origin of F-wave: involvement of central synaptic mechanisms.Brain : a journal of neurology · 2024Article
- Postinhibitory excitation in motoneurons can be facilitated by hyperpolarization-activated inward currents: A simulation study.PLoS computational biology · 2024Article
- Blind identification of the spinal cord output in humans with high-density electrode arrays implanted in muscles.Science advances · 2022Article
- Quadriceps muscle stimulation evokes heteronymous inhibition onto soleus with limited Ia activation compared to femoral nerve stimulation.Experimental brain research · 2022Article
- Spatial and Temporal Arrangement of Recurrent Inhibition in the Primate Upper Limb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- The Functional Role of Spinal Interneurons Following Traumatic Spinal Cord Injury.Frontiers in cellular neuroscience · 2020Article
- Medium latency excitatory reflex of soleus re-examined.Experimental brain research · 2019Article
- A motor physiology recurrent topic: simplify assumptions to gain extra insight.The Journal of physiology · 2019Article
- Transcranial magnetic stimulation induced early silent period and rebound activity re-examined.PloS one · 2019Article
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Abstract
key pointsTo uncover the synaptic profile of Renshaw inhibition on motoneurons, we stimulated thick motor axons and recorded from voluntarily-activated motor units. Stimuli generated a direct motor response on the whole muscle and an inhibitory response in active motor units. We have estimated the profile of Renshaw inhibition indirectly using the response of motor unit discharge rates to the stimulus. We have put forward a method of extrapolation that may be used to determine genuine synaptic potentials as they develop on motoneurons. These optimized techniques can be used in research and in clinics to fully appreciate Renshaw cell function in various neurological disorders. ABSTRACT: Although Renshaw inhibition (RI) has been extensively studied for decades, its precise role in motor control is yet to be discovered. One of the main handicaps is a lack of reliable methods for studying RI in conscious human subjects. We stimulated the lowest electrical threshold motor axons (thickest axons) in the tibial nerve and analysed the stimulus-correlated changes in discharge of voluntarily recruited low-threshold single motor units (SMUs) from the soleus muscle. In total, 54 distinct SMUs from 12 subjects were analysed. Stimuli that generated only the direct motor response (M-only) on surface electromyography induced an inhibitory response in the low-threshold SMUs. Because the properties of RI had to be estimated indirectly using the background discharge rate of SMUs, its profile varied with the discharge rate of the SMU. The duration of RI was found to be inversely proportional to the discharge rate of SMUs. Using this important finding, we have developed a method of extrapolation for estimating RI as it develops on motoneurons in the spinal cord. The frequency methods indicated that the duration of RI was between 30 and 40 ms depending on the background firing rate of the units, and the extrapolation indicated that RI on silent motoneurons was ∼55 ms. The present study establishes a novel methodology for studying RI in human subjects and hence may serve as a tool for improving our understanding of the involvement of RI in human motor control.
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