Trial reportJournal of applied oral science : revista FOB2019
Evaluating clinical and laboratory effects of ozone in non-surgical periodontal treatment: a randomized controlled trial.
Trial report in Journal of applied oral science : revista FOB, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Pooled it
- Effects of ozone therapy as an adjuvant in the treatment of periodontitis: a systematic review and meta-analysis.BMC oral health · 2025Pooled it
- Systematic review and meta-analysis on the effect of olive oil in the treatment of periodontal diseases.Frontiers in oral health · 2025Pooled it
- Ineffectiveness of ozone therapy in nonsurgical periodontal treatment: a systematic review and metaanalysis of randomized clinical trials.Clinical oral investigations · 2020Pooled it
- The Gaseous Ozone Therapy as a Promising Antiseptic Adjuvant of Periodontal Treatment: A Randomized Controlled Clinical Trial.International journal of environmental research and public health · 2022Trial
- Adjunctive Gaseous Ozone Improves Clinical and Microbiological Outcomes in Periodontitis: A Randomized Split-Mouth Study.Dentistry journal · 2026Article
- The Potential of Ozone Therapy as an Adjunct to Periodontal Treatment in Diabetes Mellitus: A Biomarkers Scoping Review.Current diabetes reviews · 2026Article
- Oxygen-Based Adjunct Therapies in Periodontitis: A Systematic Review and Meta-Analysis Within the Framework of Hypoxia and Inflammation.Biomedicines · 2025Review
- Clinical and Microbiological Study on Local Application of an Ozonated Olive Oil Gel in the Periodontal Pockets: A Randomized Double-Blind Trial.Journal of clinical medicine · 2025Article
- Effectiveness of Ozone Therapy in Non-Surgical Periodontal Treatment: A Meta-Analysis of Topical Applications.Journal of clinical medicine · 2025Review
- The Impact of Ozone on Periodontal Cell Line Viability and Function.Current issues in molecular biology · 2025Review
- Efficacy of Olive Oil, Ozonated Olive Oil, and Chlorhexidine Gel as an Adjunct to Scaling and Root Planing in Chronic Periodontitis: A Clinical Study.Journal of pharmacy & bioallied sciences · 2024Article
- The Management of Necrotizing Gingivitis in Paediatric Patients: A Scoping Review and Two Case Reports.Children (Basel, Switzerland) · 2024Article
- Identification the Low Oxidative Stress Subtype of Periodontitis.International dental journal · 2024Article
- Is Ozone a Valid Adjuvant Therapy for Periodontitis and Peri-Implantitis? A Systematic Review.Journal of personalized medicine · 2023Review
- Efficacy Ozone Therapy in Reducing Periodontal Disease.Materials (Basel, Switzerland) · 2023Article
- Potential Clinical Applications of Ozone Therapy in Dental Specialties-A Literature Review, Supported by Own Observations.International journal of environmental research and public health · 2023Review
- Ozone in Patients with Periodontitis: A Clinical and Microbiological Study.Journal of clinical medicine · 2022Article
- Biofilm disruption and bactericidal activity of aqueous ozone coupled with ultrasonic dental scaling.JADA foundational science · 2022Article
- Nanobubble Ozone Stored in Hyaluronic Acid Decorated Liposomes: Antibacterial, Anti-SARS-CoV-2 Effect and Biocompatibility Tests.International journal of nanomedicine · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aims to evaluate the clinical and biochemical (oxidative stress and pro-inflammatory mediators) effects of the gaseous ozone use accompanied by scaling and root planning (SRP) in periodontal treatment. MATERIAL AND
methodsThe study population consisted of 40 patients with chronic periodontitis (CP) randomly sorted into two groups of 20. The experimental group received SRP plus 3 watts gaseous ozone in two separate applications five days apart, whereas the control group received SRP plus placebo. Clinical periodontal parameters were assayed and saliva samples were taken before the initial and one month after the second treatment. Periodontal examination assessed plaque index (PI), gingival index (GI), probing depth, and clinical attachment level (CAL). Total antioxidant status (TAS), total oxidant status (TOS), nitric oxide (NO), 8-hydroxy-2'-deoxyguanosine (8-OHdG), myeloperoxidase (MPO), glutathione (GSH), malondialdehyde (MDA), and transforming growth factor-beta (TGF-β) levels were evaluated from saliva samples.
resultsChanges following treatment in PI, GI, probing depth, and CAL scores were similar for both groups (p>0.05). Of note, TGF-β levels were observed to be higher in the treatment group than in controls (p<0.05). Changes in 8-OHdG, TAS, TOS, NO, MPO, GSH and MDA levels, however, were not significantly different between groups (p>0.05).
conclusionThe findings of this study indicate that SRP plus gaseous ozone versus SRP alone does not correlate to a significant improvement in periodontal recovery.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.