Evidence map›Paper›PMID 30672750›Full record

ReviewCurrent opinion in allergy and clinical immunology2019

Contributions of innate lymphocytes to allergic responses.

Juan M Inclan-Rico, John J Ponessa, Mark C Siracusa

Abstract readReview
In one paragraph

Review in Current opinion in allergy and clinical immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Juan M Inclan-RicoCenter for Immunity and Inflammation.
John J PonessaCenter for Immunity and Inflammation.
Mark C SiracusaCenter for Immunity and Inflammation.
Rutgers New Jersey Medical SchoolRutgers, The State University of New Jersey · US

Funding

Protective and pathologic functions of macrophages induced by helminthsR01AI131634 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI GAUSE, WILLIAM CLARK, SIRACUSA, MARK CHRISTOPHER · 2018 to 2022
$2.6M
Innate Immune regulation of helminth-induced inflammationR01AI123224 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI SIRACUSA, MARK CHRISTOPHER · 2016 to 2020
$2.0M
NIAID NIH HHS R01 AI123224NIAID NIH HHS R01 AI131634
6 · The paper itself

Abstract

purpose of reviewAllergic diseases represent a growing global health concern, especially among pediatric populations. Current strategies for the treatment of allergies and asthma focus on limiting the severity of the symptoms; however, additional research investigating the mechanisms promoting inflammation in the context of allergic reactions may lead to the development of more effective therapeutic strategies. RECENT

findingsNovel studies have highlighted the contributions of innate lymphocytes to the induction of inflammatory responses to allergens. Remarkably, neuron-derived signals, hormones, and even vitamins have been suggested to modulate the activity of innate lymphocytes, opening new windows of opportunity for the treatment of allergic inflammation. SUMMARY: These studies highlight the complex interactions of the nervous, endocrine, and immune system that promote pathology in the context of allergic inflammation. Further studies are required to understand these interactions in order to aid in the development of novel and much-needed therapies to treat allergic conditions.

Indexed as

AllergensAnimalsHormonesHumansHypersensitivityImmunity, InnateImmunomodulationInflammationLymphocytesNeuroimmunomodulationAllergensHormones

Identifiers

PMID30672750
PMCPMC6442462
OpenAlexW2914975136

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.