Evidence map›Paper›PMID 30672735›Full record

ArticleeLife2019

S-cone photoreceptors in the primate retina are functionally distinct from L and M cones.

Jacob Baudin, Juan M Angueyra, Raunak Sinha, Fred Rieke

Abstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. High-Fidelity Backpropagation through Primate Foveal Cones.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  2. S-Cone Retinal Pathway Dysfunction in Myopia.Investigative ophthalmology & visual science · 2026
    Article
  3. HIGH-FIDELITY BACKPROPAGATION THROUGH PRIMATE FOVEAL CONES.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. S-cone-specific circuitry in the outer plexiform layer of a cone-dominant mammal.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. The non-opponent nature of colour afterimages.Communications psychology · 2025
    Article
  9. Article
  10. Photopic flicker optoretinography captures the light-driven length modulation of photoreceptors during phototransduction.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Review
  12. Dark continuous noise from visual pigment as a major mechanism underlying rod-cone difference in light sensitivity.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Cone-Opponent Ganglion Cells in the Primate Fovea Tuned to Noncardinal Color Directions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  17. Review
  18. Coexistence within one cell of microvillous and ciliary phototransductions across M1- through M6-IpRGCs.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jacob BaudinDepartment of Physiology and Biophysics, University of Washington, Seattle, United States.
Juan M AngueyraDepartment of Physiology and Biophysics, University of Washington, Seattle, United States.ORCID 0000-0002-9217-3069
Raunak SinhaDepartment of Physiology and Biophysics, University of Washington, Seattle, United States.ORCID 0000-0002-7553-1274
Fred RiekeDepartment of Physiology and Biophysics, University of Washington, Seattle, United States.ORCID 0000-0002-1052-2609

Funding

University of Washington Medical Scientist Training Program: MD/PhDT32GM007266 · NIGMS · UNIVERSITY OF WASHINGTON · PI HORWITZ, MARSHALL S. · 1985 to 2023
$30.4M
BIOPHYSICAL MECHANISMS OF SINGLE PHOTON DETECTIONR01EY011850 · NEI · UNIVERSITY OF WASHINGTON · PI RIEKE, FREDERICK M · 1997 to 2015
$3.5M
Mechanisms controlling retinal responses to natural stimuliR01EY028542 · NEI · UNIVERSITY OF WASHINGTON · PI FREDERICK M RIEKE · 2018 to 2026
$3.5M
Retinal interactions between rod and cone signalsR01EY028111 · NEI · UNIVERSITY OF WASHINGTON · PI RIEKE, FREDERICK M · 2017 to 2021
$1.9M
Role of synaptic integration in early visual processingR00EY026070 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI SINHA, RAUNAK · 2018 to 2020
$747k
Role of synaptic integration in early visual processingK99EY026070 · NEI · UNIVERSITY OF WASHINGTON · PI SINHA, RAUNAK · 2016 to 2017
$180k
ARCS Foundation ScholarHoward Hughes Medical Institute InvestigatorNEI NIH HHS K99 EY026070NEI NIH HHS R00 EY026070NEI NIH HHS R01 EY011850NEI NIH HHS R01 EY028111NEI NIH HHS R01 EY028542NIGMS NIH HHS T32 GM007266NIH HHS EY011850NIH HHS EY026070NIH HHS EY028111Simons Foundation Fellowship
6 · The paper itself

Abstract

Daylight vision starts with signals in three classes of cone photoreceptors sensitive to short (S), middle (M), and long (L) wavelengths. Psychophysical studies show that perceptual sensitivity to rapidly varying inputs differs for signals originating in S cones versus L and M cones; notably, S-cone signals appear perceptually delayed relative to L- and M-cone signals. These differences could originate in the cones themselves or in the post-cone circuitry. To determine if the cones could contribute to these and related perceptual phenomena, we compared the light responses of primate S, M, and L cones. We found that S cones generate slower light responses than L and M cones, show much smaller changes in response kinetics as background-light levels increase, and are noisier than L and M cones. It will be important to incorporate these differences into descriptions of how cone signaling shapes human visual perception.

Indexed as

Adaptation, OcularAnimalsFemaleFovea CentralisKineticsLight Signal TransductionMalePhotic StimulationPrimatesRetinal Cone Photoreceptor Cellsblue conesconesneuroscienceretinaretinal circuitryrhesus macaque

Identifiers

PMID30672735
PMCPMC6344076

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.