SynthesisPsychophysiology2019
Respiratory sinus arrhythmia reactivity across empirically based structural dimensions of psychopathology: A meta-analysis.
Synthesis in Psychophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05343039 (Leveraging Biomarkers and New Technologies to Reduce Self-Injury and Substance Abuse Risk Among Highly Vulnerable Adolescents), which is not on this map. Cited by 70 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Leveraging Biomarkers and New Technologies to Reduce Self-Injury and Substance Abuse Risk Among Highly Vulnerable Adolescents
Who cites it
70 citing papers in PubMed, 2 syntheses or guidelines pooled it, 139 citations in OpenAlex.
- Annual Research Review: What processes are dysregulated among emotionally dysregulated youth? - a systematic review.Journal of child psychology and psychiatry, and allied disciplines · 2025Pooled it
- Trauma-related dissociation and the autonomic nervous system: a systematic literature review of psychophysiological correlates of dissociative experiencing in PTSD patients.European journal of psychotraumatology · 2022Pooled it
- Is respiratory sinus arrhythmia a modifiable index of symptom change in cognitive behavioral therapy for youth? A pooled-data analysis of a randomized trial.Psychotherapy research : journal of the Society for Psychotherapy Research · 2025Trial
- The influence of pretreatment respiratory sinus arrhythmia dimensions on trauma-focused cognitive behavioral therapy outcomes: Findings from a randomized controlled feasibility trial.Journal of traumatic stress · 2024Trial
- Respiratory Sinus Arrhythmia Change during Trauma-Focused Cognitive-Behavioral Therapy: Results from a Randomized Controlled Feasibility Trial.Research on child and adolescent psychopathology · 2022Trial
- PCIT engagement and persistence among child welfare-involved families: Associations with harsh parenting, physiological reactivity, and social cognitive processes at intake.Development and psychopathology · 2022Trial
- Mindfulness-oriented recovery enhancement reduces opioid dose in primary care by strengthening autonomic regulation during meditation.The American psychologist · 2020Trial
- Negative and Positive Emotion Reactivity and Regulation in Adolescents: A Multimethod Investigation of Associations With Depressive Symptoms.Research on child and adolescent psychopathology · 2026Article
- Autonomic Interplay and the Bimodal Classification of Aggression: Baseline and Reactivity Profiles in Urban Adult Males.Psychophysiology · 2026Article
- The typical and atypical development of dynamic self-regulation and coregulation of respiratory sinus arrhythmia in mothers and children across early childhood.Child development · 2026Article
- Synchronizing brains and hearts: A practical guide for caregiver-child fNIRS-ECG multimodal hyperscanning.Behavior research methods · 2026Article
- Investigating Physiology-Behavior Associations for Youth During Parent-Child Conflict Discussions.Developmental psychobiology · 2026Article
- Article
- Associations Between Autistic Adolescents' Biological and Behavioral Characteristics and Sympathetic and Parasympathetic Functioning.Journal of autism and developmental disorders · 2026Article
- Why The Polyvagal Theory Is Untenable: An international expert evaluation of the polyvagal theory and commentary upon Porges, S.W. (2025). Polyvagal theory: current status, clinical applications, and future directions. Clin. Neuropsychiatry, 22(3), 169-184.Clinical neuropsychiatry · 2026Article
- Prolonged RSA recovery following parent-child conflict predicts reactive aggression in daily life.European child & adolescent psychiatry · 2025Article
- Development of Respiratory Sinus Arrhythmia in Young Infants With Autism Spectrum Disorder, Preterm Birth, and Typical Development.Autism research : official journal of the International Society for Autism Research · 2025Article
- A Multi-Component Model of Emotion Response Convergence: Implications for the Development of Psychopathology.Emotion review : journal of the International Society for Research on Emotion · 2025Article
- Do Infant Heart Rate Variability and Visual Attention Predict Autism and Concerns for ADHD?Journal of attention disorders · 2025Article
- Emotional Reactivity and Internalizing Symptoms in Middle Childhood: Integrating Autonomic and Behavioral Markers of Social Fear and Positive Affect.Developmental psychobiology · 2025Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Low resting respiratory sinus arrhythmia (RSA) is observed in many mental health conditions, including anxiety disorders, mood disorders, schizophrenia spectrum disorders, disruptive behavior disorders, and nonsuicidal self-injury, among others. Findings for RSA reactivity are more mixed. We evaluate associations between RSA reactivity and empirically derived structural categories of psychopathology-including internalizing, externalizing, and thought problems-among physically healthy adults. We searched multiple electronic databases for studies of RSA among participants who were assessed either dimensionally using well-validated measures or diagnostically using structured interviews. Strict inclusion criteria were used to screen 3,605 published reports, which yielded 37 studies including 2,347 participants and 76 effect sizes. We performed a meta-analysis, with meta-analytic regressions of potential moderators, including psychopathology subtypes. The sample-wide meta-analytic association between RSA reactivity and psychopathology was quite small, but heterogeneity was considerable. Moderation analyses revealed significant RSA reactivity (withdrawal) specifically in externalizing samples. Additional moderators included (a) stimulus conditions used to elicit RSA reactivity (only negative emotion inductions were effective), (b) sex (women showed greater RSA reactivity than men), and (c) adherence to established methodological guidelines (e.g., higher electrocardiographic sampling rates yielded greater RSA reactivity). These findings indicate that associations between RSA reactivity and psychopathology are complex and suggest that future studies should include more standardized RSA assessments to increase external validity and decrease measurement error.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.