Evidence map›Paper›PMID 30672466›Full record

ArticleeLife2019

PLZF targets developmental enhancers for activation during osteogenic differentiation of human mesenchymal stem cells.

Shuchi Agrawal Singh, Mads Lerdrup, Ana-Luisa R Gomes, Harmen Jg van de Werken, Jens Vilstrup Johansen, Robin Andersson, Albin Sandelin, Kristian Helin, Klaus Hansen

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 51 citations in OpenAlex.

  1. Review
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  13. Multi-omics ofFrontiers in cardiovascular medicine · 2022
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  14. Review
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  16. Article
  17. JMJD3: a critical epigenetic regulator in stem cell fate.Cell communication and signaling : CCS · 2021
    Review
  18. Article
  19. Article
  20. The Functions of the Demethylase JMJD3 in Cancer.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 4 countries.

Shuchi Agrawal SinghBiotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0001-8632-4556
Mads LerdrupBiotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-7730-8973
Ana-Luisa R GomesBiotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Harmen Jg van de WerkenDepartment of Cell Biology, University Medical Center, Rotterdam, Netherlands.ORCID https://orcid.org/0000-0002-9794-1477
Jens Vilstrup JohansenBiotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Robin AnderssonBiotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Albin SandelinBiotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-7109-7378
Kristian HelinThe Novo Nordisk Center for Stem Cell Biology, Faculty of Health and Medical Sciences University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0003-1975-6097
Klaus HansenBiotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0001-9657-8816
University of Copenhagen · DKRotterdam University of Applied Sciences · NL

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Danish National Research Foundation DNRF 82Forskerakademiet 09-073526Lundbeckfonden R34-A3479Memorial Sloan-Kettering Cancer Center Support Grant NIH P30 CA008748NCI NIH HHS P30 CA008748Novo Nordisk NNF17CC0027852
6 · The paper itself

Abstract

The PLZF transcription factor is essential for osteogenic differentiation of hMSCs; however, its regulation and molecular function during this process is not fully understood. Here, we revealed that the

Indexed as

AcetylationCell DifferentiationCell LineageChromatinEmbryonic DevelopmentEnhancer Elements, GeneticEpigenesis, GeneticGenetic LociHistonesHumansLysineMesenchymal Stem CellsNicotinamide N-MethyltransferaseOsteogenesisPromoter Regions, GeneticPromyelocytic Leukemia Zinc Finger ProteinChromatinHistonesLysineNicotinamide N-MethyltransferaseNNMT protein, humanPromyelocytic Leukemia Zinc Finger ProteinRNAZBTB16 protein, humanchromosomesdevelopmental enhancergene expressionhistone H3 lysine 27 tri-methylationhumanhuman mesenchymal stem cellsosteogenesisPLZFpolycomb proteinsPolycomb proteinsZBTB16

Identifiers

PMID30672466
PMCPMC6344081
OpenAlexW2912107157

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.