Evidence map›Paper›PMID 30672297›Full record

ArticleJournal of proteome research2019

Urine Nuclear Magnetic Resonance (NMR) Metabolomics in Age-Related Macular Degeneration.

Inês Laíns, Daniela Duarte, António S Barros, Ana Sofia Martins, Tatiana J Carneiro, João Q Gil, John B Miller, Marco Marques, Tânia S Mesquita, Patrícia Barreto and 9 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of proteome research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.

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  3. Metabolomics in Age-Related Macular Degeneration: A Systematic Review.Investigative ophthalmology & visual science · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 2 countries.

Inês LaínsDepartment of Ophthalmology , Massachusetts Eye and Ear, Harvard Medical School , Boston , Massachusetts 02115 , United States.
Daniela DuarteCICECO- Aveiro Institute of Materials (CICECO/UA), Department of Chemistry , University of Aveiro , 3810-193 Aveiro , Portugal.ORCID 0000-0001-9460-1162
António S BarrosCICECO- Aveiro Institute of Materials (CICECO/UA), Department of Chemistry , University of Aveiro , 3810-193 Aveiro , Portugal.
Ana Sofia MartinsCICECO- Aveiro Institute of Materials (CICECO/UA), Department of Chemistry , University of Aveiro , 3810-193 Aveiro , Portugal.ORCID 0000-0001-6865-5853
Tatiana J CarneiroCICECO- Aveiro Institute of Materials (CICECO/UA), Department of Chemistry , University of Aveiro , 3810-193 Aveiro , Portugal.
João Q GilFaculty of Medicine , University of Coimbra (FMUC) , 3000-354 Coimbra , Portugal.
John B MillerDepartment of Ophthalmology , Massachusetts Eye and Ear, Harvard Medical School , Boston , Massachusetts 02115 , United States.
Marco MarquesFaculty of Medicine , University of Coimbra (FMUC) , 3000-354 Coimbra , Portugal.
Tânia S MesquitaAssociation for Innovation and Biomedical Research on Light and Image (AIBILI) , 3000-548 Coimbra , Portugal.
Patrícia BarretoAssociation for Innovation and Biomedical Research on Light and Image (AIBILI) , 3000-548 Coimbra , Portugal.
Ivana K KimDepartment of Ophthalmology , Massachusetts Eye and Ear, Harvard Medical School , Boston , Massachusetts 02115 , United States.
Maria da Luz CachuloFaculty of Medicine , University of Coimbra (FMUC) , 3000-354 Coimbra , Portugal.
Demetrios G VavvasDepartment of Ophthalmology , Massachusetts Eye and Ear, Harvard Medical School , Boston , Massachusetts 02115 , United States.
Isabel M CarreiraFaculty of Medicine , University of Coimbra (FMUC) , 3000-354 Coimbra , Portugal.
Joaquim Neto MurtaFaculty of Medicine , University of Coimbra (FMUC) , 3000-354 Coimbra , Portugal.
Rufino SilvaFaculty of Medicine , University of Coimbra (FMUC) , 3000-354 Coimbra , Portugal.
Joan W MillerDepartment of Ophthalmology , Massachusetts Eye and Ear, Harvard Medical School , Boston , Massachusetts 02115 , United States.
Deeba HusainDepartment of Ophthalmology , Massachusetts Eye and Ear, Harvard Medical School , Boston , Massachusetts 02115 , United States.
Ana M GilCICECO- Aveiro Institute of Materials (CICECO/UA), Department of Chemistry , University of Aveiro , 3810-193 Aveiro , Portugal.ORCID 0000-0003-3766-4364
Massachusetts Eye and Ear Infirmary · USHospitais da Universidade de Coimbra · PTUniversity of Aveiro · PTAssociation for Innovation and Biomedical Research on Light and Image · PTUniversity of Coimbra · PT

Funding

Metabolomics a Novel Tool for Investigating the Pathogenesis of Age-related Macular DegenerationR01EY030088 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI Deeba Husain · 2020 to 2026
$3.5M
Multi-Omic Endotyping of AsthmaK01HL146980 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI KELLY, RACHEL SABINE · 2019 to 2023
$891k
NEI NIH HHS R01 EY030088NHLBI NIH HHS K01 HL146980
6 · The paper itself

Abstract

Biofluid biomarkers of age-related macular degeneration (AMD) are still lacking, and their identification is challenging. Metabolomics is well-suited to address this need, and urine is a valuable accessible biofluid. This study aimed to characterize the urinary metabolomic signatures of patients with different stages of AMD and a control group (>50 years). It was a prospective, cross-sectional study, where subjects from two cohorts were included: 305 from Coimbra, Portugal (AMD patients n = 252; controls n = 53) and 194 from Boston, United States (AMD patients n = 147; controls n = 47). For all participants, we obtained color fundus photographs (for AMD staging) and fasting urine samples, which were analyzed using

Indexed as

MetabolomicsAgedAged, 80 and overBiomarkersBody FluidsFemaleHumansMacular DegenerationMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleMiddle AgedBiomarkersage-related macular degenerationmetabolomicsnuclear magnetic resonance spectroscopyurine

Identifiers

PMID30672297
PMCPMC7838731
OpenAlexW2914322159

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.