Evidence map›Paper›PMID 30672105›Full record

Trial reportAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2019

Long-term survival in visceral transplant recipients in the new era: A single-center experience.

Ahmed M Elsabbagh, Jason Hawksworth, Khalid M Khan, Stuart S Kaufman, Nada A Yazigi, Alexander Kroemer, Coleman Smith, Thomas M Fishbein, Cal S Matsumoto

Abstract readClinical Trial
In one paragraph

Trial report in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Observational
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. CD69+ resident memory T cells are associated with graft-versus-host disease in intestinal transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021
    Article
  16. Rejection of intestinal allotransplants is driven by memory T helper type 17 immunity and responds to infliximab.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021
    Article
  17. Article
  18. Islet Transplantation in Children.Current gastroenterology reports · 2019
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ahmed M ElsabbaghMedStar Georgetown Transplant Institute, Georgetown University Hospital, Washington, District of Columbia.ORCID 0000-0003-4773-8144
Jason HawksworthMedStar Georgetown Transplant Institute, Georgetown University Hospital, Washington, District of Columbia.
Khalid M KhanMedStar Georgetown Transplant Institute, Georgetown University Hospital, Washington, District of Columbia.
Stuart S KaufmanMedStar Georgetown Transplant Institute, Georgetown University Hospital, Washington, District of Columbia.
Nada A YazigiMedStar Georgetown Transplant Institute, Georgetown University Hospital, Washington, District of Columbia.
Alexander KroemerMedStar Georgetown Transplant Institute, Georgetown University Hospital, Washington, District of Columbia.
Coleman SmithMedStar Georgetown Transplant Institute, Georgetown University Hospital, Washington, District of Columbia.
Thomas M FishbeinMedStar Georgetown Transplant Institute, Georgetown University Hospital, Washington, District of Columbia.
Cal S MatsumotoMedStar Georgetown Transplant Institute, Georgetown University Hospital, Washington, District of Columbia.

Funding

UPIT: Unleash the Potential of Intestinal TransplantationR01AI132389 · NIAID · GEORGETOWN UNIVERSITY · PI KROEMER, ALEXANDER HELMUT KURT · 2017 to 2021
$2.4M
Protective and Proinflammatory Immunological Mechanisms behind Liver Ischemia Reperfusion Injury in Marginal LiversR21AI130800 · NIAID · GEORGETOWN UNIVERSITY · PI KROEMER, ALEXANDER HELMUT KURT · 2018 to 2019
$449k
NIAID NIH HHS R01 AI132389NIAID NIH HHS R21 AI130800
6 · The paper itself

Abstract

There is a paucity of data on long-term outcomes following visceral transplantation in the contemporary era. This is a single-center retrospective analysis of all visceral allograft recipients who underwent transplant between November 2003 and December 2013 with at least 3-year follow-up data. Clinical data from a prospectively maintained database were used to assess outcomes including patient and graft survival. Of 174 recipients, 90 were adults and 84 were pediatric patients. Types of visceral transplants were isolated intestinal transplant (56.3%), combined liver-intestinal transplant (25.3%), multivisceral transplant (16.1%), and modified multivisceral transplant (2.3%). Three-, 5-, and 10-year overall patient survival was 69.5%, 66%, and 63%, respectively, while 3-, 5-, and 10-year overall graft survival was 67%, 62%, and 61%, respectively. In multivariable analysis, significant predictors of survival included pediatric recipient (P = .001), donor/recipient weight ratio <0.9 (P = .008), no episodes of severe acute rejection (P = .021), cold ischemia time <8 hours (P = .014), and shorter hospital stay (P = .0001). In conclusion, visceral transplantation remains a good option for treatment of end-stage intestinal failure with parenteral nutritional complications. Proper graft selection, shorter cold ischemia time, and improvement of immunosuppression regimens could significantly improve the long-term survival.

Indexed as

Graft SurvivalAdolescentAdultAgedChildChild, PreschoolFemaleFollow-Up StudiesHumansImmunosuppressive AgentsInfantMaleMiddle AgedOrgan TransplantationPrognosisProspective StudiesImmunosuppressive Agentsclinical research/practicehealth services and outcomes researchimmunosuppressive regimens - inductionintestinal (allograft) function/dysfunctionintestine/multivisceral transplantation

Identifiers

PMID30672105
PMCPMC6591067

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.